Versatile Fabrication Approach of Conductive Hydrogels via Copolymerization with Vinyl Monomers

被引：29

作者：

Jiang, Lin ^{[1
]}

Gentile, Carmine ^{[6
,7
]}

Lauto, Antonio ^{[8
]}

Cui, Chen ^{[1
]}

Song, Yihui ^{[1
]}

Romeo, Tony ^{[9
]}

Silva, Saimon M. ^{[2
,3
,4
]}

Tang, Owen ^{[6
]}

Sharma, Poonam ^{[6
]}

Figtree, Gemma ^{[6
]}

Gooding, J. Justin ^{[2
,3
,4
]}

Mawad, Damia ^{[1
,3
,4
,5
]}

机构：

[1] UNSW Australia, Sch Mat Sci & Engn, Sydney, NSW 2052, Australia

[2] UNSW Australia, Sch Chem, Sydney, NSW 2052, Australia

[3] UNSW Australia, Australian Ctr NanoMed, Sydney, NSW 2052, Australia

[4] UNSW Australia, ARC Ctr Excellence Convergent BioNano Sci & Techn, Sydney, NSW 2052, Australia

[5] UNSW Australia, Ctr Adv Macromol Design, Sydney, NSW 2052, Australia

[6] Univ Sydney, Sydney Med Sch Northern, Kolling Inst, Cardiothorac & Vasc Hlth, Sydney, NSW 2000, Australia

[7] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[8] Univ Western Sydney, Biomed Engn & Neurosci BENS Res Grp, Penrith, NSW 2751, Australia

[9] Univ Wollongong, Electron Microscopy Ctr, Innovation Campus,Squires Way, Wollongong, NSW 2519, Australia

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 50期

基金：

澳大利亚国家健康与医学研究理事会; 澳大利亚研究理事会;

关键词：

poly(ethylene dioxythiophene); hydrogel; conducting polymer; copolymerization; electroactive; cardiac cells; MECHANICAL-PROPERTIES; SUPERPOROUS HYDROGELS; SWELLING BEHAVIOR; POLYMER HYDROGEL; IN-VIVO; METHACRYLATE); POLY(3,4-ETHYLENEDIOXYTHIOPHENE); FIBROBLAST; SCAFFOLDS; TRANSPORT;

D O I：

10.1021/acsami.7b15019

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Functionalized poly(ethylene dioxythiophene) (f-PEDOT) was copolymerized with two vinyl monomers of different hydrophilicity, acrylic acid and hydroxyethyl methacrylate, to produce electroconductive hydrogels with a range of physical and electronic properties. These hydrogels not only possessed tailored physical properties, such as swelling ratios and mechanical properties, but also displayed electroactivity dependent on the chemical composition of the network. Raman spectroscopy indicated that the functional PEDOT in the hydrogels is in an oxidized form, most likely accounting for the good electrochemical response of the hydrogels observed in physiological buffer. In vitro cell studies showed that cardiac cells respond differently when seeded on hydrogel substrates with different compositions. This study presents a facile approach for the fabrication of electroconductive hydrogels with a range of properties, paving the way for scaffolds that can meet the requirements of different electroresponsive tissues.

引用

页码：44124 / 44133

页数：10

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