Real-Time Non-Rigid 3D Respiratory Motion Estimation for MR-Guided Radiotherapy Using MR-MOTUS

被引:19
作者
Huttinga, Niek R. F. [1 ]
Bruijnen, Tom [1 ]
Van den Berg, Cornelis A. T. [1 ]
Sbrizzi, Alessandro [1 ]
机构
[1] Univ Med Ctr Utrecht, Dept Radiotherapy, Computat Imaging Grp MR Therapy & Diagnost, NL-3584 CX Utrecht, Netherlands
基金
荷兰研究理事会;
关键词
Magnetic resonance imaging; MR-guided radiotherapy; real-time reconstruction; motion estimation; iterative reconstruction; IMAGE-RECONSTRUCTION; TUMOR-LOCALIZATION; MODEL; SYSTEM;
D O I
10.1109/TMI.2021.3112818
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
The MR-Linac is a combination of an MR-scanner and radiotherapy linear accelerator (Linac) which holds the promise to increase the precision of radiotherapy treatments with MR-guided radiotherapy by monitoring motion during radiotherapy with MRI, and adjusting the radiotherapy plan accordingly. Optimal MR-guidance for respiratory motion during radiotherapy requires MR-based 3D motion estimation with a latency of 200-500 ms. Currently this is still challenging since typical methods rely on MR-images, and are therefore limited by the 3D MR-imaging latency. In this work, we present a method to perform non-rigid 3D respiratory motion estimation with 170 ms latency, including both acquisition and reconstruction. The proposed method called real-time low-rank MR-MOTUS reconstructs motion-fields directly from k-space data, and leverages an explicit low-rank decomposition of motion-fields to split the large scale 3D+t motion-field reconstruction problem posed in our previous work into two parts: (I) a medium-scale offline preparation phase and (II) a small-scale online inference phase which exploits the results of the offline phase for real-time computations. The method was validated on free-breathing data of five volunteers, acquired with a 1.5T Elekta Unity MR-Linac. Results show that the reconstructed 3D motion-field are anatomically plausible, highly correlated with a self-navigation motion surrogate (R = 0.975 +/- 0.0110), and can be reconstructed with a total latency of 170 ms that is sufficient for real-time MR-guided abdominal radiotherapy.
引用
收藏
页码:332 / 346
页数:15
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