Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

被引：400

作者：

Martinez, Paula ^{[1
]}

Blasco, Maria A. ^{[1
]}

机构：

[1] Spanish Natl Canc Ctr CNIO, Telomeres & Telomerase Grp, Mol Oncol Program, E-28029 Madrid, Spain

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 03期

关键词：

DNA-DAMAGE RESPONSE; GENOME-WIDE ASSOCIATION; COMMON FRAGILE SITES; FACTOR-KAPPA-B; REVERSE-TRANSCRIPTASE; RNA COMPONENT; HUMAN-DISEASE; STEM-CELLS; HOMOLOGOUS RECOMBINATION; DYSKERATOSIS-CONGENITA;

D O I：

10.1038/nrc3025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are progressively lost with each round of cell division. Telomere protection requires a minimal length of TTAGGG repeats to allow the binding of shelterin, which prevents the activation of a DNA damage response (DDR) at chromosome ends. Telomere elongation is carried out by telomerase. Telomerase can also act as a transcriptional modulator of the Wnt-beta-catenin signalling pathway and has RNA-dependent RNA polymerase activity. Dysfunctional telomeres can lead to either cancer or ageing pathologies depending on the integrity of the DDR. This Review discusses the role of telomeric proteins in cancer and ageing through modulating telomere length and protection, as well as regulating gene expression by binding to non-telomeric sites.

引用

页码：161 / 176

页数：16

共 201 条

[1] TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo [J].

Abreu, Eladio ;

Aritonovska, Elena ;

Reichenbach, Patrick ;

Cristofari, Gael ;

Culp, Brad ;

Terns, Rebecca M. ;

Lingner, Joachim ;

Terns, Michael P. .

MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (12) :2971-2982

[2]

Akiyama M, 2003, CANCER RES, V63, P18

[3] Short Telomeres are Sufficient to Cause the Degenerative Defects Associated with Aging [J].

Armanios, Mary ;

Alder, Jonathan K. ;

Parry, Erin M. ;

Karim, Baktiar ;

Strong, Margaret A. ;

Greider, Carol W. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 85 (06) :823-832

[4] Telomerase mutations in families with idiopathic pulmonary fibrosis [J].

Armanios, Mary Y. ;

Chen, Julian J. -L. ;

Cogan, Joy D. ;

Alder, Jonathan K. ;

Ingersoll, Roxann G. ;

Markin, Cheryl ;

Lawson, William E. ;

Xie, Mingyi ;

Vulto, Irma ;

Phillips, John A., III ;

Lansdorp, Peter M. ;

Greider, Carol W. ;

Loyd, James E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (13) :1317-1326

[5] Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [J].

Artandi, SE ;

Chang, S ;

Lee, SL ;

Alson, S ;

Gottlieb, GJ ;

Chin, L ;

DePinho, RA .

NATURE, 2000, 406 (6796) :641-645

[6] Constitutive telomerase expression promotes mammary carcinomas in aging mice [J].

Artandi, SE ;

Alson, S ;

Tietze, MK ;

Sharpless, NE ;

Ye, S ;

Greenberg, RA ;

Castrillon, DH ;

Horner, JW ;

Weiler, SR ;

Carrasco, RD ;

DePinho, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8191-8196

[7] A critical role for telomeres in suppressing and facilitating carcinogenesis [J].

Artandi, SE ;

DePinho, RA .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (01) :39-46

[8] Telomeres and telomerase in cancer [J].

Artandi, Steven E. ;

DePinho, Ronald A. .

CARCINOGENESIS, 2010, 31 (01) :9-18

[9] Telomeres: Hallmarks of radiosensitivity [J].

Ayouaz, Ali ;

Raynaud, Christophe ;

Heride, Claire ;

Revaud, Deborah ;

Sabatier, Laure .

BIOCHIMIE, 2008, 90 (01) :60-72

[10] Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends [J].

Azzalin, Claus M. ;

Reichenbach, Patrick ;

Khoriauli, Lela ;

Giulotto, Elena ;

Lingner, Joachim .

SCIENCE, 2007, 318 (5851) :798-801

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