Delayed Viral Clearance of Chronic Hepatitis C in Patients after Treatment Failure

被引：2
作者：
Cho, Su Hyun [1 ]
Lee, Sung Wook [1 ]
Choi, Seok Reyol [1 ]
Han, Sang Young [1 ]
Roh, Myung Hwan [1 ]
Lee, Jong Hoon [1 ]
Jang, Jin Seok [1 ]
Baek, Yang Hyun [1 ]
Kim, Su Young [1 ]
机构：
[1] Dong A Univ, Coll Med, Dept Internal Med, Pusan 602715, South Korea
来源：
GUT AND LIVER | 2011年 / 5卷 / 01期
关键词：
Delayed viral clearance; Chronic hepatitis C; Sustained virological response; VIRUS-INFECTION; HCV-RNA; PEGYLATED INTERFERON; VIROLOGICAL RESPONSE; PLUS RIBAVIRIN; THERAPY; PEGINTERFERON; COMBINATION; RESOLUTION;
D O I：
10.5009/gnl.2011.5.1.110
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatitis C virus (HCV) infection usually progresses to chronic hepatitis, with rare cases of spontaneous viral eradication. We present herein four cases involving patients that were initially declared to have failed to respond to treatments, based on the presence of HCV RNA that was still detectable after completion of the standard treatment for chronic hepatitis C with genotype 2. However, the HCV RNA became undetectable, with a delayed response, after discontinuation of therapy. Two of the four patients were diagnosed as treatment failures after extended treatment, and the other two received no further treatment after the standard treatment. All four patients maintained a sustained virological response during the periodic follow-up after delayed viral clearance. (Gut Liver 2011;5:110-114)
引用
收藏
页码：110 / 114
页数：5
相关论文
共 18 条
[1]   A 5-year prospective study of the late resolution of chronic hepatitis C after antiviral therapy [J].
Annicchiarico, B. E. ;
Siciliano, M. ;
Avolio, A. W. ;
Grillo, R. L. ;
Bombardieri, G. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2007, 25 (09) :1039-1046
[2]   Thymosin Alpha-1 in Combination with Pegylated Interferon and Ribavirin in Chronic Hepatitis C Patients Who have Failed to Prior Pegylated Interferon and Ribavirin Treatment [J].
Baek, Yang Hyun ;
Lee, Sung Wook ;
Yoo, Hyun Seung ;
Yoon, Hyun Ah ;
Kim, Ja Won ;
Kim, Young Hoon ;
Kim, Ha Youn ;
Han, Sang Young .
GUT AND LIVER, 2007, 1 (01) :87-89
[3]  
Berg T, 2008, ANTIVIR THER, V13, P17
[4]   Studies of therapy with thymosin α1 in combination with pegylated interferon α2a and ribavirin in nonresponder patients with chronic hepatitis C [J].
Camerini, Roberto ;
Ciancio, Alessia ;
De Rosa, Alfonso ;
Rizzetto, Mario .
THYMOSINS IN HEALTH AND DISEASE: FIRST INTERNATIONAL SYMPOSIUM, 2007, 1112 :368-374
[5]   Pegylated interferon and ribavirin failures: Is retreatment an option? [J].
Cheruvattath, Rekha ;
Rosati, Marianne J. ;
Gautam, Manjushree ;
Vargas, Hugo E. ;
Rakela, Jorge ;
Balan, Vijayan .
DIGESTIVE DISEASES AND SCIENCES, 2007, 52 (03) :732-736
[6]   Early virologic response to treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C [J].
Davis, GL ;
Wong, JB ;
McHutchison, JG ;
Manns, MP ;
Harvey, J ;
Albrecht, J .
HEPATOLOGY, 2003, 38 (03) :645-652
[7]   Chronic hepatitis C: Viral clearance several months after discontinuation of therapy in two non-responders [J].
Denis, J. ;
Rautou, P. E. ;
Lambare, B. ;
Herbert, S. ;
Auray-Cartier, V. ;
Asselah, T. .
INFECTION, 2007, 35 (03) :197-200
[8]   Sustained disappearance of hepatitis C viremia in patients receiving protease inhibitor treatment for human immunodeficiency virus infection [J].
Fialaire, P ;
Payan, C ;
Chennebault, JM ;
Loison, J ;
Pichard, E ;
Lunel, P .
JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (02) :574-575
[9]   Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. [J].
Fried, MW ;
Shiffman, ML ;
Reddy, KR ;
Smith, C ;
Marinos, G ;
Goncales, FL ;
Haussinger, D ;
Diago, M ;
Carosi, G ;
Dhumeaux, D ;
Craxi, A ;
Lin, A ;
Hoffman, J ;
Yu, J .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (13) :975-982
[10]   Treatment of chronic hepatitis C in a slow responder: a case for extended therapy [J].
Gaglio, Paul J. .
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2009, 6 (06) :372-375
12