Treatment of systemic lupus erythematosus with mycophenolate mofetil

被引：48

作者：

Adu, D ^{[1
]}

Cross, J

Jayne, DRW

机构：

[1] Queen Elizabeth Hosp, Birmingham B15 2TH, W Midlands, England

[2] St Helier Hosp, London, England

[3] Univ London St Georges Hosp, Sch Med, Div Renal Med, London SW17 0RE, England

[4] Renal Unit, London, England

来源：

LUPUS | 2001年 / 10卷 / 03期

关键词：

lupus; nephritis; mycophenolate mofetil; treatment;

D O I：

10.1191/096120301673517315

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mycophenolate mofetil is an immunosuppressive drag that is of established efficacy in renal transplantation. It inhibits the de novo pathway of purine synthesis and therefore lymphocyte proliferation Mycophenylate mofetil has been shown to ameliorate the severity of renal injury in murine models of lupus nephritis. Recent studies suggest that it may also be effective in the treatment of patients with lupus nephritis when used in conjunction with steroids. These observations need to be confirmed in adequately sized randomised-controlled studies.

引用

页码：203 / 208

页数：6

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