Exosomes in virus-associated cancer

被引：17
作者：
Wu, Jin'en [1 ]
Yang, Jing [1 ]
Ding, Juntao [2 ]
Guo, Xiaola [1 ]
Zhu, Xing-Quan [1 ,3 ]
Zheng, Yadong [1 ,3 ]
机构：
[1] CAAS, Lanzhou Vet Res Inst, Key Lab Vet Parasitol Gansu Prov, State Key Lab Vet Etiol Biol, Lanzhou 730046, Gansu, Peoples R China
[2] Xinjiang Univ, Coll Life Sci & Technol, Urumqi 830046, Peoples R China
[3] Yangzhou Univ, Coll Vet Med, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China
来源：
CANCER LETTERS | 2018年 / 438卷
基金：
中国国家自然科学基金;
关键词：
Exosome; Onco-virus; miRNAs; Virus-associated cancer; EPSTEIN-BARR-VIRUS; HEPATITIS-C VIRUS; INFECTED-CELLS; B-VIRUS; EXTRACELLULAR VESICLES; MULTIVESICULAR BODIES; MICRORNAS; BIOGENESIS; MODULATION; EXPRESSION;
D O I：
10.1016/j.canlet.2018.09.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Exosomes are phospholipid bilayer membrane-enclosed vesicles in a size from 30 to 150 nm, carrying a variety of active components, such as proteins, mRNA and miRNAs, and are involved in intercellular communication. Exosomes are released by almost all living cells and detected in various biological fluids. Viruses especially oncogenic viruses have been reported to influence the formation of virus-associated cancer through reshaping the tumor microenvironment via exosomes. In this review, a role of exosomes released by oncogenic virus infected cells in promoting or inhibiting cancer formation is outlined. Moreover, the prospects and challenges of exosome applications in cancer therapies are critically discussed.
引用
收藏
页码：44 / 51
页数：8
相关论文
共 113 条
[21]   Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity [J].
Dreux, Marlene ;
Garaigorta, Urtzi ;
Boyd, Bryan ;
Decembre, Elodie ;
Chung, Josan ;
Whitten-Bauer, Christina ;
Wieland, Stefan ;
Chisari, Francis V. .
CELL HOST & MICROBE, 2012, 12 (04) :558-570
[22]   EBV-driven LMP1 and IFN-γ up-regulate PD-L1 in nasopharyngeal carcinoma: Implications for oncotargeted therapy [J].
Fang, Wenfeng ;
Zhang, Jianwei ;
Hong, Shaodong ;
Zhan, Jianhua ;
Chen, Nan ;
Qin, Tao ;
Tang, Yanna ;
Zhang, Yaxiong ;
Kang, Shiyang ;
Zhou, Ting ;
Wu, Xuan ;
Liang, Wenhua ;
Hu, Zhihuang ;
Ma, Yuxiang ;
Zhao, Yuanyuan ;
Tian, Ying ;
Yang, Yunpeng ;
Xue, Cong ;
Yan, Yue ;
Hou, Xue ;
Huang, Peiyu ;
Huang, Yan ;
Zhao, Hongyun ;
Zhang, Li .
ONCOTARGET, 2014, 5 (23) :12189-12202
[23]   Exosomes:: endosomal-derived vesicles shipping extracellular messages [J].
Février, B ;
Raposo, G .
CURRENT OPINION IN CELL BIOLOGY, 2004, 16 (04) :415-421
[24]   Localization of the Epstein-Barr virus protein LMP 1 to exosomes [J].
Flanagan, J ;
Middeldorp, J ;
Sculley, T .
JOURNAL OF GENERAL VIROLOGY, 2003, 84 :1871-1879
[25]   Human hepatic stellate cells are not permissive for hepatitis C virus entry and replication [J].
Florimond, Alexandre ;
Chouteau, Philippe ;
Bruscella, Patrice ;
Le Seyec, Jacques ;
Merour, Emilie ;
Ahnou, Nazim ;
Mallat, Ariane ;
Lotersztajn, Sophie ;
Pawlotsky, Jean-Michel .
GUT, 2015, 64 (06) :957-965
[26]   Kaposi sarcoma herpesvirus-associated cancers and related diseases [J].
Goncalves, Priscila H. ;
Ziegelbauer, Joseph ;
Uldrick, Thomas S. ;
Yarchoan, Robert .
CURRENT OPINION IN HIV AND AIDS, 2017, 12 (01) :47-56
[27]   Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways [J].
Goodwin, EC ;
DiMaio, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12513-12518
[28]   Extra-cellular release and blood diffusion of BART viral micro-RNAs produced by EBV-infected nasopharyngeal carcinoma cells [J].
Gourzones, Claire ;
Gelin, Aurore ;
Bombik, Izabela ;
Klibi, Jihene ;
Verillaud, Benjamin ;
Guigay, Joel ;
Lang, Philippe ;
Temam, Stephane ;
Schneider, Veronique ;
Amiel, Corinne ;
Baconnais, Sonia ;
Jimenez, Anne-Sophie ;
Busson, Pierre .
VIROLOGY JOURNAL, 2010, 7
[29]   Active Wnt proteins are secreted on exosomes [J].
Gross, Julia Christina ;
Chaudhary, Varun ;
Bartscherer, Kerstin ;
Boutros, Michael .
NATURE CELL BIOLOGY, 2012, 14 (10) :1036-+
[30]   Mechanisms of pathogen entry through the endosomal compartments [J].
Gruenberg, Jean ;
van der Goot, F. Gisou .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (07) :495-504
12345678910