Exosomes in virus-associated cancer

被引：17

作者：

Wu, Jin'en ^{[1
]}

Yang, Jing ^{[1
]}

Ding, Juntao ^{[2
]}

Guo, Xiaola ^{[1
]}

Zhu, Xing-Quan ^{[1
,3
]}

Zheng, Yadong ^{[1
,3
]}

机构：

[1] CAAS, Lanzhou Vet Res Inst, Key Lab Vet Parasitol Gansu Prov, State Key Lab Vet Etiol Biol, Lanzhou 730046, Gansu, Peoples R China

[2] Xinjiang Univ, Coll Life Sci & Technol, Urumqi 830046, Peoples R China

[3] Yangzhou Univ, Coll Vet Med, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China

来源：

CANCER LETTERS | 2018年 / 438卷

基金：

中国国家自然科学基金;

关键词：

Exosome; Onco-virus; miRNAs; Virus-associated cancer; EPSTEIN-BARR-VIRUS; HEPATITIS-C VIRUS; INFECTED-CELLS; B-VIRUS; EXTRACELLULAR VESICLES; MULTIVESICULAR BODIES; MICRORNAS; BIOGENESIS; MODULATION; EXPRESSION;

D O I：

10.1016/j.canlet.2018.09.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Exosomes are phospholipid bilayer membrane-enclosed vesicles in a size from 30 to 150 nm, carrying a variety of active components, such as proteins, mRNA and miRNAs, and are involved in intercellular communication. Exosomes are released by almost all living cells and detected in various biological fluids. Viruses especially oncogenic viruses have been reported to influence the formation of virus-associated cancer through reshaping the tumor microenvironment via exosomes. In this review, a role of exosomes released by oncogenic virus infected cells in promoting or inhibiting cancer formation is outlined. Moreover, the prospects and challenges of exosome applications in cancer therapies are critically discussed.

引用

页码：44 / 51

页数：8

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