Identification of a new imprinted gene, Rian, on mouse chromosome 12 by fluorescent differential display screening

被引：68

作者：

Hatada, I

Morita, S

Obata, Y

Sotomaru, Y

Shimoda, M

Kono, T

机构：

[1] Gunma Univ, Ctr Gene Res, Gunma 3718511, Japan

[2] Tokyo Univ Agr, Dept Biosci, Setagaya Ku, Tokyo 1568502, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2001年 / 130卷 / 02期

关键词：

androgenetic embryo; imprinting; imprinted gene; parthenogenetic embryo;

D O I：

10.1093/oxfordjournals.jbchem.a002971

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Systematic screening of differentially expressed genes among androgenetic, parthenogenetic, and normal embryos by means of fluorescent differential display revealed five imprinted genes. One of them, named Rian, was expressed exclusively from the maternal allele and was closely linked to an imprinted gene, Meg3(Gtl2), mapped to the distal end of chromosome 12. The Rian transcript did not have any apparent open reading frame, and its transcript was exclusively localized to the nucleus.

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页码：187 / 190

页数：4

相关论文

共 17 条

[1] TISSUE-SPECIFIC AND DEVELOPMENTAL STAGE-SPECIFIC IMPRINTING OF THE MOUSE PROINSULIN GENE, INS2 [J].

DELTOUR, L ;

MONTAGUTELLI, X ;

GUENET, JL ;

JAMI, J ;

PALDI, A .

DEVELOPMENTAL BIOLOGY, 1995, 168 (02) :686-688

[2]

Georgiades P, 2000, DEVELOPMENT, V127, P4719

[3] Screening for imprinted genes by allelic message display: Identification of a paternally expressed gene Impact on mouse chromosome 18 [J].

Hagiwara, Y ;

Hirai, M ;

Nishiyama, K ;

Kanazawa, I ;

Ueda, T ;

Sakaki, Y ;

Ito, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) :9249-9254

[4] A GENOMIC SCANNING METHOD FOR HIGHER ORGANISMS USING RESTRICTION SITES AS LANDMARKS [J].

HATADA, I ;

HAYASHIZAKI, Y ;

HIROTSUNE, S ;

KOMATSUBARA, H ;

MUKAI, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (21) :9523-9527

[5] Mouse Peg9/Dlk1 and human PEG9/DLK1 are paternally expressed imprinted genes closely located to the maternally expressed imprinted genes:: mouse Meg3/Gtl2 and human MEG3 [J].

Kobayashi, S ;

Wagatsuma, H ;

Ono, R ;

Ichikawa, H ;

Yamazaki, M ;

Tashiro, H ;

Aisaka, K ;

Miyoshi, N ;

Kohda, T ;

Ogura, A ;

Ohki, M ;

Kaneko-Ishino, T ;

Ishino, F .

GENES TO CELLS, 2000, 5 (12) :1029-1037

[6] A novel type of non-coding RNA expressed in the rat brain [J].

Komine, Y ;

Tanaka, NK ;

Yano, R ;

Takai, S ;

Yuasa, S ;

Shiroishi, T ;

Tsuchiya, K ;

Yamamori, T .

MOLECULAR BRAIN RESEARCH, 1999, 66 (1-2) :1-13

[7] COMPLETION OF MOUSE EMBRYOGENESIS REQUIRES BOTH THE MATERNAL AND PATERNAL GENOMES [J].

MCGRATH, J ;

SOLTER, D .

CELL, 1984, 37 (01) :179-183

[8] Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q [J].

Miyoshi, N ;

Wagatsuma, H ;

Wakana, S ;

Shiroishi, T ;

Nomura, M ;

Aisaka, K ;

Kohda, T ;

Surani, MA ;

Kaneko-Ishino, T ;

Ishino, F .

GENES TO CELLS, 2000, 5 (03) :211-220

[9] A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2 [J].

Peters, J ;

Wroe, SF ;

Wells, CA ;

Miller, HJ ;

Bodle, D ;

Beechey, CV ;

Williamson, CM ;

Kelsey, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3830-3835

[10] Genomic imprinting: Parental influence on the genome [J].

Reik, W ;

Walter, J .

NATURE REVIEWS GENETICS, 2001, 2 (01) :21-32