Neuroprotective properties of afobazol in vitro

被引:28
作者
Zenina, TA [1 ]
Gavrish, IV [1 ]
Melkumyan, DS [1 ]
Seredenina, TS [1 ]
Seredenin, SB [1 ]
机构
[1] Russian Acad Med Sci, VV Zakusov State Res Inst Pharmacol, Dept Pharmacol Genet, Moscow, Russia
关键词
afobazol; oxidative stress; glutamate toxicity; neuroprotection;
D O I
10.1007/s10517-005-0443-7
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The effects of a novel selective anxiolytic afobazol on survival of HT-22 neurons were studied in the model of oxidative stress and glutamate toxicity. In both models, the neuroprotective effect of afobazol was established.
引用
收藏
页码:194 / 196
页数:3
相关论文
共 10 条
[1]   On the dimension of projected polyhedra [J].
Balas, E ;
Oosten, M .
DISCRETE APPLIED MATHEMATICS, 1998, 87 (1-3) :1-9
[2]  
BALASANYAN MG, 2002, MED NAUKA ARMENII, V42, P25
[3]  
Gusev EI, 2001, CEREBRAL ISCHEMIA
[4]  
KERR JFR, 1995, METHOD CELL BIOL, V46, P1
[5]  
Knight JA, 1997, ANN CLIN LAB SCI, V27, P11
[6]  
Maher P, 1996, J NEUROSCI, V16, P6394
[7]  
MIRZOYAN RS, 1996, EKSP KLIN FARMAKOL, V59, P62
[8]   Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death [J].
Petersén, Å ;
Larsen, KE ;
Behr, GG ;
Romero, N ;
Przedborski, S ;
Brundin, P ;
Sulzer, D .
BRAIN RESEARCH BULLETIN, 2001, 56 (3-4) :331-335
[9]  
Seredenin S. B., 1998, Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, V0, P3
[10]  
Tan SL, 1998, J NEUROCHEM, V71, P95