Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children

被引：4

作者：

Chen, Shan ^{[1
]}

Wang, Wen-Wen ^{[1
]}

Wang, Yan ^{[1
]}

Li, Yong-Qin ^{[1
]}

Zhu, Li-Xin ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Otorhinolaryngol, Wuhan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | 2020年 / 133卷

关键词：

Recurrent tonsillitis; Tonsillar hypertrophy; Cellular senescence; EXPRESSION; DISEASE; CELLS;

D O I：

10.1016/j.ijporl.2020.110004

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Objective: To observe the difference in cellular senescence patterns between recurrent tonsillitis and tonsillar hypertrophy. Methods and materials: Forty-three patients diagnosed with recurrent tonsillitis or tonsillar hypertrophy, based on medical history and symptoms, underwent tonsillectomy. The specimens were collected and examined using senescence beta-galactosidase staining for cellular senescence. Macrophages were detected by immunochemistry. Results: Cellular senescence was found in both recurrent tonsillitis and tonsillar hypertrophy groups. The comparison of cellular senescence in microcompartments of tonsil tissue (germinal centre, mantle zone, sub-epithelial and intraepithelial) revealed a significant increase of senescent cells in germinal centres in tonsillar hypertrophy compared with that in tonsillar hypertrophy. The majority of senescent cells in both groups were CD68-positive. Conclusions: Different cellular senescence patterns were found between the two studied paediatric tonsillar diseases. Macrophage senescence may play a role in the pathogenesis of these diseases.

引用

页数：4

共 24 条

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