Drug delivery systems for oral disease applications

被引：24

作者：

Zhang, Yue ^{[1
]}

Jiang, Ruining ^{[1
]}

Lei, Lei ^{[1
]}

Yang, Yingming ^{[1
]}

Hu, Tao ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, Dept Prevent Dent, State Key Lab Oral Dis, Chengdu, Peoples R China

来源：

JOURNAL OF APPLIED ORAL SCIENCE | 2022年 / 30卷

关键词：

Delivery systems; Dental caries; Hydrogels; Nanoparticles; Periodontal disease; CALCIUM-SILICATE NANOPARTICLES; ANTIMICROBIAL ACTIVITY; PLGA NANOPARTICLES; CONTROLLED-RELEASE; GROWTH-FACTOR; PERIODONTITIS; SCAFFOLDS; HYDROGEL; CHLORHEXIDINE; CLASSIFICATION;

D O I：

10.1590/1678-7757-2021-0349

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

There are many restrictions on topical medications for the oral cavity. Various factors affect the topical application of drugs in the oral cavity, an open and complex environment. The complex physical and chemical environment of the oral cavity, such as saliva and food, will influence the effect of free drugs. Therefore, drug delivery systems have served as supporting structures or as carriers loading active ingredients, such as antimicrobial agents and growth factors (GFs), to promote antibacterial properties, tissue regeneration, and engineering for drug diffusion. These drug delivery systems are considered in the prevention and treatment of dental caries, periodontal disease, periapical disease, the delivery of anesthetic drugs, etc. These carrier materials are designed in different ways for clinical application, including nanoparticles, hydrogels, nanofibers, films, and scaffolds. This review aimed to summarize the advantages and disadvantages of different carrier materials. We discuss synthesis methods and their application scope to provide new perspectives for the development and preparation of more favorable and effective local oral drug delivery systems.

引用

页数：12

共 111 条

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