Neglected Comorbidity of Chronic Heart Failure: Iron Deficiency

被引:20
作者
Manceau, Hana [1 ,2 ]
Ausseil, Jerome [3 ]
Masson, Damien [4 ]
Feugeas, Jean-Paul [5 ]
Sablonniere, Bernard [6 ]
Guieu, Regis [7 ]
Puy, Herve [1 ,2 ]
Peoc'h, Katell [1 ,2 ]
机构
[1] Univ Paris, Inflammat Res Ctr CRI, INSERM UMRs 1149, F-75018 Paris, France
[2] Hop Xavier Bichat, AP HP, Dept Biochem, F-75018 Paris, France
[3] Univ Paul Sabatier, CHU Toulouse, INSERM UMR 1291, CNRS UMR 5051,Infin,Lab Biochem & Mol Biol, F-31024 Toulouse 3, France
[4] Nantes Univ Hosp, Fac Med, Dept Biochem, F-44000 Nantes, France
[5] Univ Bourgogne Franche Comte, Hop Jean Minjoz, Interact Hote Greffon Tumeur Ingn Cellulaire & Ge, UMR1098,Lab Biochim,INSERM,EFS BFC, F-25000 Besancon, France
[6] Univ Lille, CHU Lille,Ctr Biol Pathol & Genet, JPArc Ctr Rech Jean Pierre AUBERT, Inst Biochim & Biol Mol,UMR S 1172,INSERM, F-59000 Lille, France
[7] Aix Marseille Univ, Assistance Publ Hop, Ctr Cardiovasc & Nutr Res, INRAE,Lab Biochem,INSERM, F-13005 Marseille, France
关键词
iron deficiency; heart failure; transferrin saturation coefficient; serum ferritin; ferric carboxymaltose; REDUCED EJECTION FRACTION; FERRIC CARBOXYMALTOSE; EXERCISE CAPACITY; ANEMIA; DIAGNOSIS; GUIDELINES; HF; ASSOCIATION; MANAGEMENT; THERAPY;
D O I
10.3390/nu14153214
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Iron deficiency is a significant comorbidity of heart failure (HF), defined as the inability of the myocardium to provide sufficient blood flow. However, iron deficiency remains insufficiently detected. Iron-deficiency anemia, defined as a decrease in hemoglobin caused by iron deficiency, is a late consequence of iron deficiency, and the symptoms of iron deficiency, which are not specific, are often confused with those of HF or comorbidities. HF patients with iron deficiency are often rehospitalized and present reduced survival. The correction of iron deficiency in HF patients is associated with improved functional capacity, quality of life, and rehospitalization rates. Because of the inflammation associated with chronic HF, which complicates the picture of nutritional deficiency, only the parenteral route can bypass the tissue sequestration of iron and the inhibition of intestinal iron absorption. Given the negative impact of iron deficiency on HF progression, the frequency and financial implications of rehospitalizations due to decompensation episodes, and the efficacy of this supplementation, screening for this frequent comorbidity should be part of routine testing in all HF patients. Indeed, recent European guidelines recommend screening for iron deficiency (serum ferritin and transferrin saturation coefficient) in all patients with suspected HF, regular iron parameters assessment in all patients with HF, and intravenous iron supplementation in symptomatic patients with proven deficiency. We thus aim to summarize all currently available data regarding this common and easily improvable comorbidity.
引用
收藏
页数:9
相关论文
共 61 条
[1]   Anemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies [J].
Anand, Inder S. ;
Gupta, Pankaj .
CIRCULATION, 2018, 138 (01) :80-98
[2]   Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: an individual patient data meta-analysis [J].
Anker, Stefan D. ;
Kirwan, Bridget-Anne ;
van Veldhuisen, Dirk J. ;
Filippatos, Gerasimos ;
Comin-Colet, Josep ;
Ruschitzka, Frank ;
Luscher, Thomas F. ;
Arutyunov, Gregory P. ;
Motro, Michael ;
Mori, Claudio ;
Roubert, Bernard ;
Pocock, Stuart J. ;
Ponikowski, Piotr .
EUROPEAN JOURNAL OF HEART FAILURE, 2018, 20 (01) :125-133
[3]   Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency. [J].
Anker, Stefan D. ;
Comin Colet, Josep ;
Filippatos, Gerasimos ;
Willenheimer, Ronnie ;
Dickstein, Kenneth ;
Drexler, Helmut ;
Luescher, Thomas F. ;
Bart, Boris ;
Banasiak, Waldemar ;
Niegowska, Joanna ;
Kirwan, Bridget-Anne ;
Mori, Claudio ;
Rothe, Barbara von Eisenhart ;
Pocock, Stuart J. ;
Poole-Wilson, Philip A. ;
Ponikowski, Piotr .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (25) :2436-2448
[4]   Rationale and design of Ferinject® Assessment in patients with IRon deficiency and chronic Heart Failure (FAIR-HF) study: a randomized, placebo-controlled study of intravenous iron supplementation in patients with and without anaemia [J].
Anker, Stefan D. ;
Colet, Josep Comin ;
Filippatos, Gerasimos ;
Willenheimer, Ronnie ;
Dickstein, Kenneth ;
Drexler, Helmut ;
Luescher, Thomas F. ;
Mori, Claudio ;
Rothe, Barbara von Eisenhart ;
Pocock, Stuart ;
Poole-Wilson, Philip A. ;
Ponikowski, Piotr .
EUROPEAN JOURNAL OF HEART FAILURE, 2009, 11 (11) :1084-1091
[5]  
[Anonymous], 2022, Instruction DGOS/r4/2022/210 du 28 septembre 2022 relative a la mise en oeuvre de la reforme des autorisations d'activite des soins medicaux et de readaptation
[6]  
[Anonymous], 2011, HAUTE AUTORITE SANTE
[7]  
Arutyunov G., 2009, EUR J HEART FAIL, V8, pii71
[8]   Intravenous iron [J].
Auerbach, Michael ;
Rodgers, George M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (01) :93-94
[9]   The Safety of Intravenous Iron Preparations: Systematic Review and Meta-analysis [J].
Avni, Tomer ;
Bieber, Amir ;
Grossman, Alon ;
Green, Hefziba ;
Leibovici, Leonard ;
Gafter-Gvili, Anat .
MAYO CLINIC PROCEEDINGS, 2015, 90 (01) :12-23
[10]   Phenotyping heart failure patients for iron deficiency and use of intravenous iron therapy: data from the Swedish Heart Failure Registry [J].
Becher, Peter Moritz ;
Schrage, Benedikt ;
Benson, Lina ;
Fudim, Marat ;
Cabrera, Carin Corovic ;
Dahlstrom, Ulf ;
Rosano, Giuseppe M. C. ;
Jankowska, Ewa A. ;
Anker, Stefan D. ;
Lund, Lars H. ;
Savarese, Gianluigi .
EUROPEAN JOURNAL OF HEART FAILURE, 2021, 23 (11) :1844-1854