Unnarmicins A and C, new antibacterial depsipeptides produced by marine bacterium Photobacterium sp MBIC06485

被引：42

作者：

Oku, Naoya ^{[1
]}

Kawabata, Kazutaka ^{[1
]}

Adachi, Kyoko ^{[1
]}

Katsuta, Atsuko ^{[1
]}

Shizuri, Yoshikazu ^{[1
]}

机构：

[1] Marine Biotechnol Inst Co Ltd, Kamaishi, Iwate 0260001, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 01期

关键词：

unnarmicin; antibacterial; Photobacterium; marine bacterium;

D O I：

10.1038/ja.2008.103

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new antibiotic depsipeptides, unnarmicins C (1) and A (2), were isolated from the fermentation broth of a marine bacterium, Photobacterium sp. strain MBIC06485. The structure of 1 was established by spectroscopic studies and chiral analyses of its chemical degradation/conversion products, and that of 2 by comparing its NMR, MS, and CD data with those of 1. Both compounds selectively inhibited the growth of two strains belonging to the genus Pseudovibrio, one of the most prevalent genera in the marine environments within the class Alphaproteobacteria.

引用

页码：11 / 17

页数：7

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