Kawasaki disease in childhood and psychiatric disorders: A population-based case-control prospective study in Taiwan

被引：8

作者：

Chen, Daniel Tzu-Li ^{[1
,2
,3
,4
]}

Chang, Jane Pei-Chen ^{[2
,3
,4
,5
]}

Cheng, Szu-Wei ^{[2
,3
,5
]}

Chang, Hui-Chih ^{[2
,3
]}

Hsu, Jong-Hau ^{[6
]}

Chang, Hen-Hong ^{[7
,8
,9
]}

Chiu, Wei-Che ^{[10
,11
]}

Su, Kuan-Pin ^{[2
,3
,4
,5
,12
]}

机构：

[1] China Med Univ, Sch Chinese Med, Coll Chinese Med, Taichung, Taiwan

[2] China Med Univ Hosp, Dept Psychiat, Taichung, Taiwan

[3] China Med Univ Hosp, MindBody Interface Lab, MBI Lab, Taichung, Taiwan

[4] China Med Univ, Grad Inst Biomed, Coll Med, Taichung, Taiwan

[5] China Med Univ, Sch Med, Coll Med, Taichung, Taiwan

[6] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Pediat, Kaohsiung, Taiwan

[7] China Med Univ, Grad Inst Integrated Med, Coll Chinese Med, Taichung, Taiwan

[8] China Med Univ, Chinese Med Res Ctr, Taichung, Taiwan

[9] China Med Univ Hosp, Dept Chinese Med, Taichung, Taiwan

[10] Fu Jen Catholic Univ, Sch Med, Taipei, Taiwan

[11] Cathay Gen Hosp, Dept Psychiat, 280 Renai Rd Sec4, Taipei 106, Taiwan

[12] China Med Univ, Nan Hosp, Tainan, Taiwan

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2022年 / 100卷

关键词：

Inflammation; Intravenous immunoglobulin (IVIG); Kawasaki disease; National Health Insurance Research Database; (NHIRD); Psychiatric disorders; DEFICIT HYPERACTIVITY DISORDER; AGE-OF-ONSET; NATIONWIDE; INFLAMMATION; ASSOCIATION; INHIBITION; DEPRESSION; ANEURYSMS;

D O I：

10.1016/j.bbi.2021.11.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Kawasaki disease (KD) is a common childhood acute inflammatory disease and potentially triggers a chronic inflammation. Although some researches have investigated neurodevelopmental consequences following KD, the findings have been inconsistent. This is the first population-based study targeted on KD and common psychiatric disorders. Objectives: We aimed to investigate the association between KD and psychiatric disorders and hypothesized that standard anti-inflammatory treatment by intravenous immunoglobulin (IVIG) may protect against development of psychiatric disorders. Method: We retrieved data from Taiwan's National Health Insurance Research database (NHIRD). Patients (n = 282,513) with psychiatric disorders (the case group) during 1997-2013 were included, and the control group was matched with age, sex, income and urbanization (1:1). We calculated the prevalence of KD in both groups and estimated odd ratios (ORs) and 95% confidence intervals (CIs) in the subgroup analyses for KD in conditions of age, severity, and common psychiatric comorbidity. Results: Numbers of patients with KD were 460 in the cases and 380 in the controls (p = .006), and the crude OR of KD was 1.21 times greater (95% CI = 1.06-1.39, p = .006) in the case than the control groups. KD patients without IVIG treatment (n = 126) were higher in the cases than those in the controls (n = 54), with the OR of 2.33 (95% CI = 1.70-3.21, p < .0001). Subgroup analyses showed that KD survivors were at significant risk for autism spectrum disorders (ASD) (OR = 2.15, 95% CI = 1.27-3.65; p = .005) and attention deficit and hyperactivity disorders (ADHD) (OR = 1.19, 95% CI = 1.02-1.39; p = 0.03), and a trend of increased risk for anxiety disorders (OR = 1.36, 95%CI = 0.99-1.86; p = 0.05). Conclusions: Patients with KD were more likely to have comorbid psychiatric disorders, including ASD and ADHD. Moreover, anti-inflammatory treatment with IVIG may have potential prophylactic effects against the development of psychiatric disorders.

引用

页码：105 / 111

页数：7

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