Water-soluble fluorescent sensor for Zn2+ with high selectivity and sensitivity imaging in living cells

被引：11

作者：

Liu, Daying ^{[1
,2
]}

Zhang, Tingting ^{[1
]}

Zhang, Mingyang ^{[1
]}

Shi, Jun ^{[1
]}

Yin, Lihui ^{[1
]}

Shang, Zhiqiang ^{[1
]}

Zhu, Hualing ^{[1
]}

Yang, Guangming ^{[2
]}

He, Huarui ^{[3
]}

机构：

[1] Tianjin Agr Univ, Coll Basic Sci, Chem Expt Teaching Ctr, Tianjin, Peoples R China

[2] Nankai Univ, Dept Chem, Key Lab Adv Energy Mat Chem, Minist Educ, Tianjin, Peoples R China

[3] Heowns Biochem Technol LLC, Tianjin, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2020年 / 30卷 / 08期

关键词：

Fluorescent sensor; Naphthalimide; PET; Water-soluble; Zinc; AQUEOUS-SOLUTION; ZINC IONS; CHEMOSENSOR; DEATH; PROBE; CD2+;

D O I：

10.1016/j.bmcl.2020.127073

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new water-soluble 4-amino-1, 8-naphthalimide based fluorescent sensor, with iminoacetic acid and iminoethoxyacetic acid as receptor contained two different arms, was developed. Under physiological pH conditions, it demonstrates good water solubility, high selectivity and sensitivity for sensing Zn2+ with about 20-fold enhancement in aqueous solution, with a characteristic emission band of 4-amino-1, 8-naphthalimide with a green color centered at 550 nm. It was applied successfully to detect Zn2+ in living cells.

引用

页数：4

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