Metabolic features of macrophages in inflammatory diseases and cancer

被引：71

作者：

Na, Yi Rang

Je, Sungmo

Seok, Seung Hyeok ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Macrophage Lab, Dept Microbiol & Immunol, 103 Daehak Ro, Seoul 110799, South Korea

来源：

CANCER LETTERS | 2018年 / 413卷

基金：

新加坡国家研究基金会;

关键词：

Macrophages; Metabolism; Inflammatory diseases; Cancer; VESICULAR STOMATITIS-VIRUS; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; MITOCHONDRIAL CITRATE CARRIER; SUBCAPSULAR SINUS MACROPHAGES; SECRETED LACTIC-ACID; MYCOBACTERIUM-TUBERCULOSIS; NLRP3; INFLAMMASOME; IMMUNE-RESPONSE; ALPHA-ENOLASE; PPAR-GAMMA;

D O I：

10.1016/j.canlet.2017.10.044

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Macrophages are now considered to be important players in various inflammatory diseases as well as tumor progression. Emerging evidence reveals that macrophage metabolic features are deeply associated with their immune functions. Understanding the interaction between cellular metabolism and immune signaling pathways in macrophages can help us to develop appropriate therapeutic approaches for inflammatory diseases. In this review, we briefly summarize key metabolic features of M1 and M2 macrophages as well as signaling interactions between major metabolic molecules with TLRs and NLRs. Current knowledges of cellular metabolism are focused on macrophages in various disease situations including sepsis, atherosclerosis, obesity, tuberculosis and cancer. Novel insights and present targets for regulating macrophage metabolism are also discussed. (c) 2017 Elsevier B.V. All rights reserved.

引用

页码：46 / 58

页数：13

共 160 条

[1] IL-17 inhibits adipogenesis in part via C/EBPα, PPARγ and Kruppel-like factors [J].

Ahmed, Mushtaq ;

Gaffen, Sarah L. .

CYTOKINE, 2013, 61 (03) :898-905

[2] p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism [J].

Ak, Prashanth ;

Levine, Arnold J. .

FASEB JOURNAL, 2010, 24 (10) :3643-3652

[3] Control of the innate immune response by the mevalonate pathway [J].

Akula, Murali K. ;

Shi, Man ;

Jiang, Zhaozhao ;

Foster, Celia E. ;

Miao, David ;

Li, Annie S. ;

Zhang, Xiaoman ;

Gavin, Ruth M. ;

Forde, Sorcha D. ;

Germain, Gail ;

Carpenter, Susan ;

Rosadini, Charles V. ;

Gritsman, Kira ;

Chae, Jae Jin ;

Hampton, Randolph ;

Silverman, Neal ;

Gravallese, Ellen M. ;

Kagan, Jonathan C. ;

Fitzgerald, Katherine A. ;

Kastner, Daniel L. ;

Golenbock, Douglas T. ;

Bergo, Martin O. ;

Wang, Donghai .

NATURE IMMUNOLOGY, 2016, 17 (08) :922-+

[4] Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages [J].

Arts, Rob J. W. ;

Plantinga, Theo S. ;

Tuit, Sander ;

Ulas, Thomas ;

Heinhuis, Bas ;

Tesselaar, Marika ;

Sloot, Yvette ;

Adema, Gosse J. ;

Joosten, Leo A. B. ;

Smit, Johannes W. A. ;

Netea, Mihai G. ;

Schultze, Joachim L. ;

Netea-Maier, Romana T. .

ONCOIMMUNOLOGY, 2016, 5 (12)

[5] α-Enolase Expressed on the Surfaces of Monocytes and Macrophages Induces Robust Synovial Inflammation in Rheumatoid Arthritis [J].

Bae, Seyeon ;

Kim, Hyemin ;

Lee, Naeun ;

Won, Cheolhee ;

Kim, Hang-Rae ;

Hwang, Young-il ;

Song, Yeong Wook ;

Kang, Jae Seung ;

Lee, Wang Jae .

JOURNAL OF IMMUNOLOGY, 2012, 189 (01) :365-372

[6] Inflammation and cancer: back to Virchow? [J].

Balkwill, F ;

Mantovani, A .

LANCET, 2001, 357 (9255) :539-545

[7] An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ [J].

Banks, Alexander S. ;

McAllister, Fiona E. ;

Camporez, Joao Paulo G. ;

Zushin, Peter-James H. ;

Jurczak, Michael J. ;

Laznik-Bogoslavski, Dina ;

Shulman, Gerald I. ;

Gygi, Steven P. ;

Spiegelman, Bruce M. .

NATURE, 2015, 517 (7534) :391-U581

[8] Novel insights in the regulation and function of macrophages in the tumor microenvironment [J].

Bolli, Evangelia ;

Movahedi, Kiavash ;

Laoui, Damya ;

Van Ginderachter, Jo A. .

CURRENT OPINION IN ONCOLOGY, 2017, 29 (01) :55-61

[9] GAS-LIQUID-CHROMATOGRAPHIC ANALYSIS OF SYNOVIAL-FLUID - SUCCINIC ACID AND LACTIC-ACID AS MARKERS FOR SEPTIC ARTHRITIS [J].

BORENSTEIN, DG ;

GIBBS, CA ;

JACOBS, RP .

ARTHRITIS AND RHEUMATISM, 1982, 25 (08) :947-953

[10] Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation [J].

Bosca, Lisardo ;

Gonzalez-Ramos, Silvia ;

Prieto, Patricia ;

Fernandez-Velasco, Maria ;

Mojena, Marina ;

Martin-Sanz, Paloma ;

Alemany, Susana .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2015, 43 :740-744

← 1 2 3 4 5 6 7 8 9 10 →