Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors

被引:239
作者
Singh, Mohan [1 ]
Chaudhry, Parvesh [1 ]
Asselin, Eric [1 ]
机构
[1] Univ Quebec Trois Rivieres, Dept Biol Chem, Res Grp Mol Oncol & Endocrinol, Trois Rivieres, PQ G8Y 5H7, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
LEUKEMIA INHIBITORY FACTOR; PERIIMPLANTATION MOUSE UTERUS; I IGF-I; MENSTRUAL-CYCLE; FACTOR-BETA; GENE-EXPRESSION; FACTOR-RECEPTOR; MESSENGER-RNA; MICE LACKING; FACTOR LIF;
D O I
10.1530/JOE-10-0461
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The prerequisite of successful implantation depends on achieving the appropriate embryo development to the blastocyst stage and at the same time the development of an endometrium that is receptive to the embryo. Implantation is a very intricate process, which is controlled by a number of complex molecules like hormones, cytokines, and growth factors and their cross talk. A network of these molecules plays a crucial role in preparing receptive endometrium and blastocyst. Furthermore, timely regulation of the expression of embryonic and maternal endometrial growth factors and cytokines plays a major role in determining the fate of embryo. Most of the existing data comes from animal studies due to ethical issues. In this study, we comprehend the data from both animal models and humans for better understanding of implantation and positive outcomes of pregnancy. The purpose of this review is to describe the potential roles of embryonic and uterine factors in implantation process such as prostaglandins, cyclooxygenases, leukemia inhibitory factor, interleukin (IL) 6, IL11, transforming growth factor-beta, IGF, activins, NODAL, epidermal growth factor (EGF), and heparin binding-EGF. Understanding the function of these players will help us to address the reasons of implantation failure and infertility. Journal of Endocrinology (2011) 210, 5-14
引用
收藏
页码:5 / 14
页数:10
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