Progress and Principle of Drug Nanocrystals for Tumor Targeted Delivery

被引：22
作者：
Bai, Meng [1 ]
Yang, Mingshi [2 ]
Gong, Junbo [3 ]
Xu, Hui [4 ]
Wei, Zhenping [1 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, Dept Pharmaceut Engn, Tianjin 300350, Peoples R China
[2] Univ Copenhagen, Fac Pharmaceut Sci, Univ Pk 2, DK-2100 Copenhagen, Denmark
[3] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China
[4] Shenyang Pharmaceut Univ, Sch Pharm, Benxi 117004, Peoples R China
来源：
AAPS PHARMSCITECH | 2021年 / 23卷 / 01期
基金：
中国国家自然科学基金;
关键词：
drug nanocrystals; drug targeted delivery; active targeting stimulating response; surface modification; ZN FERRITE NANOCRYSTALS; FOLIC-ACID; IN-VITRO; PACLITAXEL-NANOCRYSTALS; MAGNETIC NANOPARTICLES; QUERCETIN NANOCRYSTALS; CARBON NANOTUBES; BLOCK-COPOLYMERS; HYALURONIC-ACID; LUNG-CANCER;
D O I：
10.1208/s12249-021-02200-w
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Drugs are referred to as drug nanocrystals when they exist as nanoscale crystal structures. This kind of nanocarrier has been widely utilized to increase the solubility and absorption for poorly aqueous soluble drugs after oral administration, or prolong the drug circulation when intravenous administration. The systemic cytotoxicity caused by antitumor drugs usually come from the nonspecific drug distribution. To solve the disadvantage of poor targetability, drug nanocrystals for tumor targeted delivery have been developed in recent years. In this review, the targeting mechanisms of various surface modified drug nanocrystals are introduced with the focus on passive targeting, active targeting and stimuli-responsive targeting in details. Function and application of common surface modified materials are also discussed.
引用
收藏
页数：21
相关论文
共 126 条
  • [21] Identifying the correlation between drug/stabilizer properties and critical quality attributes (CQAs) of nanosuspension formulation prepared by wet media milling technology
    George, Maya
    Ghosh, Indrajit
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 48 (1-2) : 142 - 152
  • [22] Redox-responsive theranostic nanoplatforms based on inorganic nanomaterials
    Han, Lu
    Zhang, Xiao-Yong
    Wang, Yu-Long
    Li, Xi
    Yang, Xiao-Hong
    Huang, Min
    Hu, Kun
    Li, Lu-Hai
    Wei, Yen
    [J]. JOURNAL OF CONTROLLED RELEASE, 2017, 259 : 40 - 52
  • [23] Doxorubicin and Fe3O4 loaded albumin nanoparticles with folic acid modified dextran surface for tumor diagnosis and therapy
    Hao, Hequn
    Ma, Qingming
    He, Fen
    Yao, Ping
    [J]. JOURNAL OF MATERIALS CHEMISTRY B, 2014, 2 (45) : 7978 - 7987
  • [24] Glutathione triggered degradation of polydopamine to facilitate controlled drug release for synergic combinational cancer treatment
    Hao, Ya-Nan
    Zheng, An-Qi
    Guo, Ting-Ting
    Shu, Yang
    Wang, Jian-Hua
    Johnson, Omar
    Chen, Wei
    [J]. JOURNAL OF MATERIALS CHEMISTRY B, 2019, 7 (43) : 6742 - 6750
  • [25] [何小龙 He Xiaolong], 2016, [中国医院药学杂志, Chinese Journal of Hospital Pharmacy], V36, P289
  • [26] Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: Lessons learned of the EPR effect and image-guided drug delivery
    Hollis, Christin P.
    Weiss, Heidi L.
    Leggas, Markos
    Evers, B. Mark
    Gemeinhart, Richard A.
    Li, Tonglei
    [J]. JOURNAL OF CONTROLLED RELEASE, 2013, 172 (01) : 12 - 21
  • [27] HOU WM, 1985, CHEM PHARM BULL, V33, P3986
  • [28] Hou Z, ADV RES MAT ENG CHEM, P503
  • [29] Redox-Responsive Polycation-Functionalized Cotton Cellulose Nanocrystals for Effective Cancer Treatment
    Hu, Hao
    Yuan, Wei
    Liu, Fu-Sheng
    Cheng, Gang
    Xu, Fu-Jian
    Ma, Jie
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (16) : 8942 - 8951
  • [30] RGD-modified PEGylated paclitaxel nanocrystals with enhanced stability and tumor-targeting capability
    Huang, Zhi-gang
    Lv, Feng-mei
    Wang, Jun
    Ca, Shui-juan
    Liu, Zhe-peng
    Liu, Yu
    Lu, Wei-yue
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 556 : 217 - 225
12345678910