Progress and Principle of Drug Nanocrystals for Tumor Targeted Delivery

被引：26

作者：

Bai, Meng ^{[1
]}

Yang, Mingshi ^{[2
]}

Gong, Junbo ^{[3
]}

Xu, Hui ^{[4
]}

Wei, Zhenping ^{[1
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, Dept Pharmaceut Engn, Tianjin 300350, Peoples R China

[2] Univ Copenhagen, Fac Pharmaceut Sci, Univ Pk 2, DK-2100 Copenhagen, Denmark

[3] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China

[4] Shenyang Pharmaceut Univ, Sch Pharm, Benxi 117004, Peoples R China

来源：

AAPS PHARMSCITECH | 2021年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

drug nanocrystals; drug targeted delivery; active targeting stimulating response; surface modification; ZN FERRITE NANOCRYSTALS; FOLIC-ACID; IN-VITRO; PACLITAXEL-NANOCRYSTALS; MAGNETIC NANOPARTICLES; QUERCETIN NANOCRYSTALS; CARBON NANOTUBES; BLOCK-COPOLYMERS; HYALURONIC-ACID; LUNG-CANCER;

D O I：

10.1208/s12249-021-02200-w

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Drugs are referred to as drug nanocrystals when they exist as nanoscale crystal structures. This kind of nanocarrier has been widely utilized to increase the solubility and absorption for poorly aqueous soluble drugs after oral administration, or prolong the drug circulation when intravenous administration. The systemic cytotoxicity caused by antitumor drugs usually come from the nonspecific drug distribution. To solve the disadvantage of poor targetability, drug nanocrystals for tumor targeted delivery have been developed in recent years. In this review, the targeting mechanisms of various surface modified drug nanocrystals are introduced with the focus on passive targeting, active targeting and stimuli-responsive targeting in details. Function and application of common surface modified materials are also discussed.

引用

页数：21

共 126 条

[1] Folic Acid-Functionalized, Condensed Magnetic Nanoparticles for Targeted Delivery of Doxorubicin to Tumor Cancer Cells Overexpressing the Folate Receptor [J].

Angelopoulou, Athina ;

Kolokithas-Ntoukas, Argiris ;

Fytas, Christos ;

Avgoustakis, Konstantinos .

ACS OMEGA, 2019, 4 (26) :22214-22227

[2] Mn-doped Zinc Sulphide nanocrystals for immunofluorescent labeling of epidermal growth factor receptors on cells and clinical tumor tissues [J].

Aswathy, J. ;

Seethalekshmy, N., V ;

Hiran, K. R. ;

Bindhu, M. R. ;

Manzoor, K. ;

Nair, Shantikumar V. ;

Menon, Deepthy .

NANOTECHNOLOGY, 2014, 25 (44)

[3] The Delivery Strategy of Paclitaxel Nanostructured Lipid Carrier Coated with Platelet Membrane [J].

Bang, Ki-Hyun ;

Na, Young-Guk ;

Huh, Hyun Wook ;

Hwang, Sung-Joo ;

Kim, Min-Soo ;

Kim, Minki ;

Lee, Hong-Ki ;

Cho, Cheong-Weon .

CANCERS, 2019, 11 (06)

[4]

Baselga J, 2002, ONCOLOGIST, V7, P2

[5] The simultaneous delivery of paclitaxel and Herceptin® using solid lipid nanoparticles: In vitro evaluation [J].

Buyukkoroglu, Gulay ;

Senel, Behiye ;

Gezgin, Seval ;

Tan Dinh .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2016, 35 :98-105

[6] pH-Sensitive ZnO Quantum Dots-Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery [J].

Cai, Xiaoli ;

Luo, Yanan ;

Zhang, Weiying ;

Du, Dan ;

Lin, Yuehe .

ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (34) :22442-22450

[7] Ligand-Modified Cell Membrane Enables the Targeted Delivery of Drug Nanocrystals to Glioma [J].

Chai, Zhilan ;

Ran, Danni ;

Lu, Linwei ;

Zhan, Changyou ;

Ruan, Huitong ;

Hu, Xuefeng ;

Xie, Cao ;

Jiang, Kuan ;

Li, Jinyang ;

Zhou, Jianfen ;

Wang, Jing ;

Zhang, Yanyu ;

Fang, Ronnie H. ;

Zhang, Liangfang ;

Lu, Weiyue .

ACS NANO, 2019, 13 (05) :5591-5601

[8] Lipid insertion enables targeted functionalization of paclitaxel-loaded erythrocyte membrane nanosystem by tumor-penetrating bispecific recombinant protein [J].

Chen, Hong ;

Sha, Huizi ;

Zhang, Lianru ;

Qian, Hanqing ;

Chen, Fangjun ;

Ding, Naiqin ;

Ji, Liulian ;

Zhu, Anqing ;

Xu, Qiuping ;

Meng, Fanyan ;

Yu, Lixia ;

Zhou, Yan ;

Liu, Baorui .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2018, 13 :5347-5359

[9] Sequentially Site-Specific Delivery of Apoptotic Protein and Tumor-Suppressor Gene for Combination Cancer Therapy [J].

Chen, Xiaojie ;

Zhu, Qiuwen ;

Xu, Xiao ;

Shen, Shiyang ;

Zhang, Ying ;

Mo, Ran .

SMALL, 2019, 15 (40)

[10] Tunable conjugation densities of camptothecin on hyaluronic acid for tumor targeting and reduction-triggered release [J].

Chen, Zhoujiang ;

He, Nan ;

Chen, Maohua ;

Zhao, Long ;

Li, Xiaohong .

ACTA BIOMATERIALIA, 2016, 43 :195-207

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