Progress and Principle of Drug Nanocrystals for Tumor Targeted Delivery

被引：22
作者：
Bai, Meng [1 ]
Yang, Mingshi [2 ]
Gong, Junbo [3 ]
Xu, Hui [4 ]
Wei, Zhenping [1 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, Dept Pharmaceut Engn, Tianjin 300350, Peoples R China
[2] Univ Copenhagen, Fac Pharmaceut Sci, Univ Pk 2, DK-2100 Copenhagen, Denmark
[3] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China
[4] Shenyang Pharmaceut Univ, Sch Pharm, Benxi 117004, Peoples R China
来源：
AAPS PHARMSCITECH | 2021年 / 23卷 / 01期
基金：
中国国家自然科学基金;
关键词：
drug nanocrystals; drug targeted delivery; active targeting stimulating response; surface modification; ZN FERRITE NANOCRYSTALS; FOLIC-ACID; IN-VITRO; PACLITAXEL-NANOCRYSTALS; MAGNETIC NANOPARTICLES; QUERCETIN NANOCRYSTALS; CARBON NANOTUBES; BLOCK-COPOLYMERS; HYALURONIC-ACID; LUNG-CANCER;
D O I：
10.1208/s12249-021-02200-w
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Drugs are referred to as drug nanocrystals when they exist as nanoscale crystal structures. This kind of nanocarrier has been widely utilized to increase the solubility and absorption for poorly aqueous soluble drugs after oral administration, or prolong the drug circulation when intravenous administration. The systemic cytotoxicity caused by antitumor drugs usually come from the nonspecific drug distribution. To solve the disadvantage of poor targetability, drug nanocrystals for tumor targeted delivery have been developed in recent years. In this review, the targeting mechanisms of various surface modified drug nanocrystals are introduced with the focus on passive targeting, active targeting and stimuli-responsive targeting in details. Function and application of common surface modified materials are also discussed.
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页数：21
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