The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis

被引：66
作者：
Wagstaff, Laura [2 ]
Kelwick, Richard [1 ]
Decock, Julie [1 ]
Edwards, Dylan R. [1 ]
机构：
[1] Univ E Anglia, Sch Biol Sci, Biomed Res Ctr, Norwich NR4 7JT, Norfolk, England
[2] Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2011年 / 16卷
关键词：
ADAMTS; Metalloproteinase; Thrombospondin Type-1 Repeat; Angiogenesis; Metastasis; Review; FACTOR-CLEAVING PROTEASE; SQUAMOUS-CELL CARCINOMA; HUMAN BREAST-CARCINOMA; MATRIX METALLOPROTEINASES; NASOPHARYNGEAL CARCINOMA; THROMBOSPONDIN MOTIFS; EXTRACELLULAR-MATRIX; ENZYMATIC-ACTIVITY; ENDOTHELIAL-CELLS; EXPRESSION;
D O I：
10.2741/3827
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The human ADAMTS (a disintegrin and metalloproteinase with thrombospondin-like motifs) family of 19 secreted, multidomain proteolytic enzymes is involved in a wide range of biological processes including ECM assembly and degradation, hemostasis, organogenesis and the regulation of angiogenesis. Defects in certain family members give rise to inherited human genetic diseases, while aberrant expression of other ADAMTSs has been linked to the pathogenesis of arthritis and cancer. Several ADAMTSs act as tumor or metastasis suppressors whose functions are lost either by mutation or epigenetic silencing during tumor progression. This review looks in depth at the involvement of ADAMTSs as positive and negative mediators in cancer growth and spread.
引用
收藏
页码：1861 / 1872
页数：12
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