Wnt/β-Catenin Signaling in Neural Stem Cell Homeostasis and Neurological Diseases

被引：91

作者：

Gao, Juanmei ^{[1
,2
]}

Liao, Yuan ^{[1
]}

Qiu, Mengsheng ^{[1
,2
]}

Shen, Wanhua ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Coll Life & Environm Sci, Zhejiang Key Lab Organ Dev & Regenerat, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ, Coll Life & Sci, Hangzhou, Zhejiang, Peoples R China

来源：

NEUROSCIENTIST | 2021年 / 27卷 / 01期

关键词：

neural stem cell homeostasis; Wnt/beta-catenin signaling; neurological diseases; spinal cord injury; depression; Alzheimer's disease; Parkinson's disease; ADULT HIPPOCAMPAL NEUROGENESIS; BETA-CATENIN; OPTIC TECTUM; RADIAL GLIA; PROGENITOR PROLIFERATION; NEURONAL DIFFERENTIATION; PROMOTES PROLIFERATION; EMERGING ROLES; WNT PATHWAY; MOUSE MODEL;

D O I：

10.1177/1073858420914509

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neural stem/progenitor cells (NSCs) maintain the ability of self-renewal and differentiation and compose the complex nervous system. Wnt signaling is thought to control the balance of NSC proliferation and differentiation via the transcriptional coactivator beta-catenin during brain development and adult tissue homeostasis. Disruption of Wnt signaling may result in developmental defects and neurological diseases. Here, we summarize recent findings of the roles of Wnt/beta-catenin signaling components in NSC homeostasis for the regulation of functional brain circuits. We also suggest that the potential role of Wnt/beta-catenin signaling might lead to new therapeutic strategies for neurological diseases, including, but not limited to, spinal cord injury, Alzheimer's disease, Parkinson's disease, and depression.

引用

页码：58 / 72

页数：15

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