Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

被引：521
作者：
Jopling, Chris [1 ]
Boue, Stephanie [1 ]
Izpisua Belmonte, Juan Carlos [1 ,2 ]
机构：
[1] Ctr Regenerat Med Barcelona, Barcelona 08003, Spain
[2] Salk Inst Biol Studies, La Jolla, CA 92037 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 02期
关键词：
EMBRYONIC STEM-CELLS; ZEBRAFISH HEART REGENERATION; PANCREATIC BETA-CELL; BONE-MARROW NICHE; LENS REGENERATION; DEFINED FACTORS; SELF-RENEWAL; TRANSCRIPTION FACTORS; NEUREGULIN RECEPTOR; INTERACTION NETWORK;
D O I：
10.1038/nrm3043
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming. Recent advances have shown that the addition of a group of genes can not only restore pluripotency in a fully differentiated cell state (reprogramming) but can also induce the cell to proliferate (dedifferentiation) or even switch to another cell type (transdifferentiation). Current research aims to understand how these processes work and to eventually harness them for use in regenerative medicine.
引用
收藏
页码：79 / 89
页数：11
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