Lung function and exercise capacity 6 months after hospital discharge for critical COVID-19

被引：11

作者：

Kattainen, Salla ^{[1
,2
,10
]}

Lindahl, Anna ^{[2
,3
]}

Vasankari, Tuula ^{[3
,4
]}

Ollila, Henriikka ^{[1
,2
]}

Volmonen, Kirsi ^{[5
,6
]}

Piirila, Paivi ^{[2
,6
,7
]}

Kauppi, Paula ^{[6
,8
]}

Paajanen, Juuso ^{[6
,8
]}

Kreivi, Hanna-Riikka ^{[6
,8
]}

Ulenius, Linda ^{[9
]}

Varpula, Tero ^{[1
,2
]}

Aro, Miia ^{[3
]}

Reijula, Jere ^{[6
,8
]}

Hastbacka, Johanna ^{[1
,2
]}

机构：

[1] Helsinki Univ Hosp, Div Intens Care, Dept Anaesthesiol Intens Care & Pain Med, Helsinki, Finland

[2] Univ Helsinki, Fac Med, Helsinki, Finland

[3] Finnish Lung Hlth Assoc, Helsinki, Finland

[4] Univ Turku, Fac Med, Dept Pulm Dis & Clin Allergol, Turku, Finland

[5] Univ Helsinki, HUS Diagnost Ctr, Radiol, Helsinki, Finland

[6] Helsinki Univ Hosp, Helsinki, Finland

[7] Univ Helsinki, HUS Med Diagnost Ctr, Unit Clin Physiol, Helsinki, Finland

[8] Univ Helsinki, Pulmonol Heart & Lung Ctr, Helsinki, Finland

[9] Helsinki Univ Hosp, Dept Internal Med & Rehabil, Div Physiotherapy, Helsinki, Finland

[10] Meilahti Tower Hosp, Intens Care Unit, Bldg 1,Haartmaninkatu 4, Helsinki 00290, Finland

来源：

BMC PULMONARY MEDICINE | 2022年 / 22卷 / 01期

关键词：

COVID-19; ARDS; Critical care; Lung function; Exercise capacity; 6-MINUTE WALK; DIFFUSING-CAPACITY; SURVIVORS; OUTCOMES; CONSEQUENCES; OBESITY;

D O I：

10.1186/s12890-022-02023-w

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background The significant morbidity caused by COVID-19 necessitates further understanding of long-term recovery. Our aim was to evaluate long-term lung function, exercise capacity, and radiological findings in patients after critical COVID-19. Methods Patients who received treatment in ICU for COVID-19 between March 2020 and January 2021 underwent pulmonary function tests, a 6MWD and CXR 6 months after hospital discharge. Results A restrictive ventilatory defect was found in 35% (23/65) and an impaired diffusing capacity in 52% (32/62) at 6 months. The 6-minute walk distance was reduced in 33% (18/55), and 7% (4/55) of the patients had reduced exercise capacity. Chest X-ray was abnormal in 78% (52/67) at 6 months after hospital discharge. Conclusion A significant number of patients had persisting lung function impairment and radiological abnormalities at 6 months after critical COVID-19. Reduced exercise capacity was rare.

引用

页数：10

共 44 条

[1] LONG-TERM CLINICAL OUTCOMES IN SURVIVORS OF SEVERE ACUTE RESPIRATORY SYNDROME (SARS) AND MIDDLE EAST RESPIRATORY SYNDROME (MERS) CORONAVIRUS OUTBREAKS AFTER HOSPITALISATION OR ICU ADMISSION: A SYSTEMATIC REVIEW AND META-ANALYSIS [J].

Ahmed, Hassaan ;

Patel, Kajal ;

Greenwood, Darren C. ;

Halpin, Stephen ;

Lewthwaite, Penny ;

Salawu, Abayomi ;

Eyre, Lorna ;

Breen, Andrew ;

O'Connor, Rory ;

Jones, Anthony ;

Sivan, Manoj .

JOURNAL OF REHABILITATION MEDICINE, 2020, 52 (05)

[2] Medium-term impact of COVID-19 on pulmonary function, functional capacity and quality of life [J].

Anastasio, Fabio ;

Barbuto, Sarah ;

Scarnecchia, Elisa ;

Cosma, Paolo ;

Fugagnoli, Alessandro ;

Rossi, Giulio ;

Parravicini, Mirco ;

Parravicini, Pierpaolo .

EUROPEAN RESPIRATORY JOURNAL, 2021, 58 (03)

[3] Long-term impact of COVID-19 associated acute respiratory distress syndrome [J].

Aranda, Judit ;

Oriol, Isabel ;

Martin, Miguel ;

Feria, Lucia ;

Vazquez, Nuria ;

Rhyman, Nicolas ;

Vall-Llosera, Estel ;

Pallares, Natalia ;

Coloma, Ana ;

Pestana, Melani ;

Loureiro, Jose ;

Guell, Elena ;

Borjabad, Beatriz ;

Leon, Elena ;

Franz, Elena ;

Domenech, Anna ;

Pintado, Sara ;

Contra, Anna ;

del Senor Cortes, Maria ;

Chivite, Ivan ;

Cliville, Raquel ;

Vacas, Montserrat ;

Miguel Ceresuela, Luis ;

Carratala, Jordi .

JOURNAL OF INFECTION, 2021, 83 (05) :581-588

[4] Pulmonary long-term consequences of COVID-19 infections after hospital discharge [J].

Blanco, Jose-Ramon ;

Cobos-Ceballos, Maria -Jesus ;

Navarro, Francisco ;

Sanjoaquin, Isabel ;

de las Revillas, Francisco Arnaiz ;

Bernal, Enrique ;

Buzon-Martin, Luis ;

Viribay, Miguel ;

Romero, Lourdes ;

Espejo-Perez, Simona ;

Valencia, Borja ;

Ibanez, David ;

Ferrer-Pargada, Diego ;

Malia, Damian ;

Gutierrez-Herrero, Fernando -Gustavo ;

Olalla, Julian ;

Jurado-Gamez, Bernabe ;

Ugedo, Javier .

CLINICAL MICROBIOLOGY AND INFECTION, 2021, 27 (06) :892-896

[5] Epidemiology and outcome of acute lung injury in European intensive care units - Results from the ALIVE study [J].

Brun-Buisson, C ;

Minelli, C ;

Bertolini, G ;

Brazzi, L ;

Pimentel, J ;

Lewandowski, K ;

Bion, J ;

Rornand, JA ;

Villar, J ;

Thorsteinsson, A ;

Damas, P ;

Armaganidis, A ;

Lemaire, FO .

INTENSIVE CARE MEDICINE, 2004, 30 (01) :51-61

[6] ATS statement: Guidelines for the six-minute walk test [J].

Crapo, RO ;

Casaburi, R ;

Coates, AL ;

Enright, PL ;

MacIntyre, NR ;

McKay, RT ;

Johnson, D ;

Wanger, JS ;

Zeballos, RJ ;

Bittner, V ;

Mottram, C .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 166 (01) :111-117

[7] The effect of obesity on diffusing capacity (DLCO) and the diffusing capacity adjusted for alveolar volume (DL/VA) [J].

Dagher, HN ;

Bartter, T ;

Kass, J ;

Pratter, MR .

CHEST, 2004, 126 (04) :799S-799S

[8] Result of one-year, prospective follow-up of intensive care unit survivors after SARS-CoV-2 pneumonia [J].

Eberst, Guillaume ;

Claude, Frederic ;

Laurent, Lucie ;

Meurisse, Aurelia ;

Roux-Claude, Pauline ;

Barnig, Cindy ;

Vernerey, Dewi ;

Paget-Bailly, Sophie ;

Bouiller, Kevin ;

Chirouze, Catherine ;

Behr, Julien ;

Grillet, Franck ;

Ritter, Ophelie ;

Karaer, Sinan ;

Pili-Floury, Sebastien ;

Winiszewski, Hadrien ;

Samain, Emmanuel ;

Decavel, Pierre ;

Capellier, Gilles ;

Westeel, Virginie .

ANNALS OF INTENSIVE CARE, 2022, 12 (01)

[9] Reference equations for the six-minute walk in healthy adults [J].

Enright, PL ;

Sherrill, DL .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 158 (05) :1384-1387

[10] Six-Month Pulmonary Impairment after Severe COVID-19: A Prospective, Multicentre Follow-Up Study [J].

Faverio, Paola ;

Luppi, Fabrizio ;

Rebora, Paola ;

Busnelli, Sara ;

Stainer, Anna ;

Catalano, Martina ;

Parachini, Luca ;

Monzani, Anna ;

Galimberti, Stefania ;

Bini, Francesco ;

Bodini, Bruno Dino ;

Betti, Monia ;

De Giacomi, Federica ;

Scarpazza, Paolo ;

Oggionni, Elisa ;

Scartabellati, Alessandro ;

Bilucaglia, Luca ;

Ceruti, Paolo ;

Modina, Denise ;

Harari, Sergio ;

Caminati, Antonella ;

Valsecchi, Maria Grazia ;

Bellani, Giacomo ;

Foti, Giuseppe ;

Pesci, Alberto .

RESPIRATION, 2021, 100 (11) :1078-1087

← 1 2 3 4 5 →