Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostic and therapy

被引：1123

作者：

Huang, Xiaohua ^{[1
]}

Jain, Prashant K. ^{[1
]}

El-Sayed, Ivan H. ^{[1
]}

El-Sayed, Mostafa A. ^{[1
]}

机构：

[1] Georgia Inst Technol, Laser Dynam Lab, Sch Chem & Biochem, Atlanta, GA 30332 USA

来源：

NANOMEDICINE | 2007年 / 2卷 / 05期

关键词：

cancer diagnostics; gold nanoparticles; gold nanorods; plasmonic photothermal therapy; Mie scattering; surface-enhanced Raman scattering; two-photon luminescence;

D O I：

10.2217/17435889.2.5.681

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent years have seen tremendous progress in the design and study of nanomaterials geared towards biological and biomedical applications, most notable among these being the noble metal nanoparticles. In this review, we outline the surface-plasmon resonance-enhanced optical properties of colloidal gold nanoparticles directed towards recent biomedical applications with an emphasis on cancer diagnostics and therapeutics. Methods of molecular-specific diagnostics/detection of cancer, including strongly enhanced surface plasmon resonance light-scattering, surface-enhanced emission of gold nanorods and surf ace-enhanced Raman scattering, are described. We also discuss the plasmonic photothermal therapy of cancer achieved by using the strongly enhanced surface-plasmon resonance absorption of gold nanospheres and nanorods.

引用

页码：681 / 693

页数：13

共 171 条

[11] High-sensitivity detection of DNA hybridization on microarrays using resonance light scattering [J].

Bao, P ;

Frutos, AG ;

Greef, C ;

Lahiri, J ;

Muller, U ;

Peterson, TC ;

Warden, L ;

Xie, XY .

ANALYTICAL CHEMISTRY, 2002, 74 (08) :1792-1797

[12] Applications of Carbon Nanotubes in Biotechnology and Biomedicine [J].

Bekyarova, Elena ;

Ni, Yingchun ;

Malarkey, Erik B. ;

Montana, Vedrana ;

McWilliams, Jared L. ;

Haddon, Robert C. ;

Parpura, Vladimir .

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2005, 1 (01) :3-17

[13]

Beljebbar A, 1997, J RAMAN SPECTROSC, V28, P159

[14] Functionalisation of magnetic nanoparticles for applications in biomedicine [J].

Berry, CC ;

Curtis, ASG .

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2003, 36 (13) :R198-R206

[15] Biomedical applications of functionalised carbon nanotubes [J].

Bianco, A ;

Kostarelos, K ;

Partidos, CD ;

Prato, M .

CHEMICAL COMMUNICATIONS, 2005, (05) :571-577

[16]

Bohren C. F., 1983, ABSORPTION SCATTERIN

[17] Superparamagnetic agents in magnetic resonance imaging: Physicochemical characteristics and clinical applications - A review [J].

Bonnemain, B .

JOURNAL OF DRUG TARGETING, 1998, 6 (03) :167-174

[18] Characterization of nanoplasmonic structures by locally excited photoluminescence [J].

Bouhelier, A ;

Beversluis, MR ;

Novotny, L .

APPLIED PHYSICS LETTERS, 2003, 83 (24) :5041-5043

[19] PHOTOINDUCED LUMINESCENCE FROM THE NOBLE-METALS AND ITS ENHANCEMENT ON ROUGHENED SURFACES [J].

BOYD, GT ;

YU, ZH ;

SHEN, YR .

PHYSICAL REVIEW B, 1986, 33 (12) :7923-7936

[20] Semiconductor nanocrystals as fluorescent biological labels [J].

Bruchez, M ;

Moronne, M ;

Gin, P ;

Weiss, S ;

Alivisatos, AP .

SCIENCE, 1998, 281 (5385) :2013-2016

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