Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostic and therapy

被引：1118
作者：
Huang, Xiaohua [1 ]
Jain, Prashant K. [1 ]
El-Sayed, Ivan H. [1 ]
El-Sayed, Mostafa A. [1 ]
机构：
[1] Georgia Inst Technol, Laser Dynam Lab, Sch Chem & Biochem, Atlanta, GA 30332 USA
来源：
NANOMEDICINE | 2007年 / 2卷 / 05期
关键词：
cancer diagnostics; gold nanoparticles; gold nanorods; plasmonic photothermal therapy; Mie scattering; surface-enhanced Raman scattering; two-photon luminescence;
D O I：
10.2217/17435889.2.5.681
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Recent years have seen tremendous progress in the design and study of nanomaterials geared towards biological and biomedical applications, most notable among these being the noble metal nanoparticles. In this review, we outline the surface-plasmon resonance-enhanced optical properties of colloidal gold nanoparticles directed towards recent biomedical applications with an emphasis on cancer diagnostics and therapeutics. Methods of molecular-specific diagnostics/detection of cancer, including strongly enhanced surface plasmon resonance light-scattering, surface-enhanced emission of gold nanorods and surf ace-enhanced Raman scattering, are described. We also discuss the plasmonic photothermal therapy of cancer achieved by using the strongly enhanced surface-plasmon resonance absorption of gold nanospheres and nanorods.
引用
收藏
页码：681 / 693
页数：13
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