Environmental pollutants damage airway epithelial cell cilia: Implications for the prevention of obstructive lung diseases

被引：67
作者：
Cao, Yu [1 ]
Chen, Miao [1 ]
Dong, Dan [1 ]
Xie, Songbo [1 ]
Liu, Min [1 ]
机构：
[1] Shandong Normal Univ, Shandong Prov Key Lab Anim Resistance Biol, Collaborat Innovat Ctr Cell Biol Univ Shandong, Coll Life Sci,Inst Biomed Sci, Jinan, Peoples R China
来源：
THORACIC CANCER | 2020年 / 11卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Airway epithelium; environmental pollutant; lung disease; mucociliary clearance; SULFUR-DIOXIDE; BREAST-CANCER; INDOOR AIR; EXPRESSION; EXPOSURE; OVEREXPRESSION; BIODIVERSITY; INFLAMMATION; DYSKINESIA; MOTILITY;
D O I：
10.1111/1759-7714.13323
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mucociliary epithelium lining the upper and lower respiratory tract constitutes the first line of defense of the airway and lungs against inhaled pollutants and pathogens. The concerted beating of multiciliated cells drives mucociliary clearance. Abnormalities in both the structure and function of airway cilia have been implicated in obstructive lung diseases. Emerging evidence reveals a close correlation between lung diseases and environmental stimuli such as sulfur dioxide and tobacco particles. However, the underlying mechanism remains to be described. In this review, we emphasize the importance of airway cilia in mucociliary clearance and discuss how environmental pollutants affect the structure and function of airway cilia, thus shedding light on the function of airway cilia in preventing obstructive lung diseases and revealing the negative effects of environmental pollutants on human health.
引用
收藏
页码：505 / 510
页数：6
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