How to Plumb a Pisces: Understanding Vascular Development and Disease Using Zebrafish Embryos

被引：119
作者：
Hogan, Benjamin M. [1 ]
Schulte-Merker, Stefan [2 ,3 ]
机构：
[1] Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, 306 Carmody Rd, Brisbane, Qld 4072, Australia
[2] WWU Munster, Inst Cardiovasc Organogenesis & Regenerat, Fac Med, D-48149 Munster, Germany
[3] WWU Munster, Cells Mot Cluster Excellence EXC 1003, D-48149 Munster, Germany
来源：
DEVELOPMENTAL CELL | 2017年 / 42卷 / 06期
基金：
英国医学研究理事会;
关键词：
ENDOTHELIAL-GROWTH-FACTOR; SIGNALING PATHWAY; FACTOR-C; LYMPHATIC DEVELOPMENT; NETWORK FORMATION; REDUNDANT ROLES; CELL BEHAVIORS; ANGIOGENESIS; ARTERIAL; NOTCH;
D O I：
10.1016/j.devcel.2017.08.015
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Our vasculature plays diverse and critical roles in homeostasis and disease. In recent decades, the use of zebrafish has driven our understanding of vascular development into new areas, identifying new genes and mechanisms controlling vessel formation and allowing unprecedented observation of the cellular and molecular events that shape the developing vasculature. Here, we highlight key mechanisms controlling formation of the zebrafish vasculature and investigate how knowledge from this highly tractable model system has informed our understanding of vascular disease in humans.
引用
收藏
页码：567 / 583
页数：17
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