Variations in maternal care in infancy regulate the development of stress reactivity

被引：414
作者：
Caldji, C [1 ]
Diorio, J [1 ]
Meaney, MJ [1 ]
机构：
[1] McGill Univ, Douglas Hosp, Res Ctr, Dev Neuroendocrinol Lab, Verdun, PQ H4H 1R3, Canada
来源：
BIOLOGICAL PSYCHIATRY | 2000年 / 48卷 / 12期
关键词：
maternal care; stress reactivity; GABA(A) receptor; corticotropin-releasing factor;
D O I：
10.1016/S0006-3223(00)01084-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Naturally occurring variations in maternal care in early postnatal life are associated with the development of individual differences in behavioral and hypothalamic-pituitary-adrenal responses to stress in the rat. These effects appear to be mediated by the influence of maternal licking/grooming an the development of central systems that serve to activate (corticotropin-releasing factor) or inhibit (gamma -aminobutyric acid) the expression of behavioral and endocrine responses to stress through effects on forebrain noradrenergic systems, Importantly, individual differences in maternal care are transmitted from mother to daughter, providing a mechanism for the behavioral transmission of individual differences in stress reactivity across generations, (C) 2000 Society of Biological Psychiatry.
引用
收藏
页码：1164 / 1174
页数：11
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