TGF-beta signalling in colon carcinogenesis

被引：129
作者：
Lampropoulos, Pavlos [1 ]
Zizi-Sermpetzoglou, Adamantia [2 ]
Rizos, Spyros [1 ]
Kostakis, Alkiviadis [3 ]
Nikiteas, Nikolaos [3 ]
Papavassiliou, Athanasios G. [4 ]
机构：
[1] Tzaneio Gen Hosp, Dept Surg 1, Athens, Greece
[2] Tzaneio Gen Hosp, Dept Pathol, Athens, Greece
[3] Univ Athens, Sch Med, Dept Propaedeut Surg 2, GR-11527 Athens, Greece
[4] Univ Athens, Sch Med, Dept Biol Chem, GR-11527 Athens, Greece
来源：
CANCER LETTERS | 2012年 / 314卷 / 01期
关键词：
TGF-beta signalling pathway; Colorectal cancer (CRC); Targeted therapy; GROWTH-FACTOR BETA-1; HUMAN COLORECTAL-CANCER; MICROSATELLITE INSTABILITY; SOLUBLE BETAGLYCAN; TUMOR-SUPPRESSOR; LIVER METASTASIS; GENE-MUTATIONS; IMMUNE CELLS; II RECEPTOR; SMAD4;
D O I：
10.1016/j.canlet.2011.09.041
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer remains the most common cancer and the second leading cause of cancer mortality in Europe. There are a number of pathways that have been implicated in colorectal carcinogenesis, including TGF-beta (TGF-beta)/Smad signalling pathway. The TGF-beta pathway is involved in several biological processes, including cell proliferation, differentiation, migration and apoptosis. Here we review the role of TGF-beta signalling cascade in colorectal carcinogenesis and provide some new molecular insights that may aid efforts towards targeted antitumor therapies. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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页码：1 / 7
页数：7
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