Selective NaOH-catalysed hydration of aromatic nitriles to amides

被引：24

作者：

Schmid, Thibault E. ^{[1
]}

Gomez-Herrera, Alberto ^{[1
]}

Songis, Olivier ^{[1
]}

Sneddon, Deborah ^{[1
]}

Revolte, Antoine ^{[1
]}

Nahra, Fady ^{[1
]}

Cazin, Catherine S. J. ^{[1
]}

机构：

[1] Univ St Andrews, Sch Chem, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland

来源：

CATALYSIS SCIENCE & TECHNOLOGY | 2015年 / 5卷 / 05期

关键词：

COMPLEXES; ACID; HYDROLYSIS; CONVERSION; EFFICIENT; WATER; MECHANISM; ORGANONITRILES; PALLADIUM(II); ACTIVATION;

D O I：

10.1039/c5cy00313j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The selective synthesis of aromatic and heteroaromatic amides through base-catalysed hydration of nitriles was achieved using inexpensive and commercially available NaOH as the only catalyst. A wide range of nitriles was selectively converted to their corresponding amides. Kinetic studies show that the double hydration of nitriles towards undesirable carboxylic acids is negligible under our reaction conditions.

引用

页码：2865 / 2868

页数：4

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