Targeting regulated cell death (RCD) with small-molecule compounds in cancer therapy: A revisited review of apoptosis, autophagy-dependent cell death and necroptosis

被引：34

作者：

Liu, Wei

Jin, Wenke

Zhu, Shiou

Chen, Yi ^{[1
]}

Liu, Bo ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

来源：

DRUG DISCOVERY TODAY | 2022年 / 27卷 / 02期

关键词：

Regulated cell death (RCD); Apoptosis; Autophagy-dependent cell death; Necroptosis; Small-molecule compound; Cancer therapy; DNA-DAMAGE; PHOSPHORYLATION; PROLIFERATION; SUPPRESSES; MECHANISMS; DISCOVERY; CASPASE-8; AMPK;

D O I：

10.1016/j.drudis.2021.10.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Evasion of regulated cell death (RCD), mainly referring to apoptosis, autophagy-dependent cell death, necroptosis, and other subroutines, is one of the well-established hallmarks of cancer cells. Accumulating evidence has revealed several small-molecule compounds that target different subroutines of RCD in cancer therapy. In this review, we summarize key pathways of apoptosis, autophagy-dependent cell death and necroptosis in cancer, and describe small-molecule compounds that target these pathways and have potential as therapeutics. These inspiring findings light the way towards the discovery of more 'magic bullets' that could work individually or cooperatively to target precisely the three RCD subroutines and so improve cancer treatment.

引用

页码：612 / 625

页数：14

共 67 条

[1] A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo [J].

Bai, Longchuan ;

Zhou, Haibin ;

Xu, Renqi ;

Zhao, Yujun ;

Chinnaswamy, Krishnapriya ;

McEachern, Donna ;

Chen, Jianyong ;

Yang, Chao-Yie ;

Liu, Zhaomin ;

Wang, Mi ;

Liu, Liu ;

Jiang, Hui ;

Wen, Bo ;

Kumar, Praveen ;

Meagher, Jennifer L. ;

Sun, Duxin ;

Stuckey, Jeanne A. ;

Wang, Shaomeng .

CANCER CELL, 2019, 36 (05) :498-+

[2] A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development [J].

Boege, Yannick ;

Malehmir, Mohsen ;

Healy, Marc E. ;

Bettermann, Kira ;

Lorentzen, Anna ;

Vucur, Mihael ;

Ahuja, Akshay K. ;

Bohm, Friederike ;

Mertens, Joachim C. ;

Shimizu, Yutaka ;

Frick, Lukas ;

Remouchamps, Caroline ;

Mutreja, Karun ;

Kaehne, Thilo ;

Sundaravinayagam, Devakumar ;

Wolf, Monika J. ;

Rehrauer, Hubert ;

Koppe, Christiane ;

Speicher, Tobias ;

Padrissa-Altes, Susagna ;

Maire, Renaud ;

Schattenberg, Jo Rn M. ;

Jeong, Ju-Seong ;

Liu, Lei ;

Zwirner, Stefan ;

Boger, Regina ;

Hueser, Norbert ;

Davis, Roger J. ;

Mullhaupt, Beat ;

Moch, Holger ;

Schulze-Bergkamen, Henning ;

Clavien, Pierre-Alain ;

Werner, Sabine ;

Borsig, Lubor ;

Luther, Sanjiv A. ;

Jost, Philipp J. ;

Weinlich, Ricardo ;

Unger, Kristian ;

Behrens, Axel ;

Hillert, Laura ;

Dillon, Christopher ;

Di Virgilio, Michela ;

Wallach, David ;

Dejardin, Emmanuel ;

Zender, Lars ;

Naumann, Michael ;

Walczak, Henning ;

Green, Douglas R. ;

Lopes, Massimo ;

Lavrik, Inna .

CANCER CELL, 2017, 32 (03) :342-+

[3]

Bonora M, 2015, ONCOGENE, V34, P1608, DOI [10.1038/onc.2014.462, 10.1038/onc.2014.96]

[4] Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer [J].

Cao, Ya ;

Wang, Jinglong ;

Tian, Hua ;

Fu, Guo-Hui .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2020, 39 (01)

[5] Targeting apoptosis in cancer therapy [J].

Carneiro, Benedito A. ;

El-Deiry, Wafik S. .

NATURE REVIEWS CLINICAL ONCOLOGY, 2020, 17 (07) :395-417

[6] Cedrol suppresses glioblastoma progression by triggering DNA damage and blocking nuclear translocation of the androgen receptor [J].

Chang, Kai-Fu ;

Huang, Xiao-Fan ;

Chang, Jinghua Tsai ;

Huang, Ya-Chih ;

Weng, Jun-Cheng ;

Tsai, Nu-Man .

CANCER LETTERS, 2020, 495 :180-190

[7] A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells [J].

Chefetz, Ilana ;

Grimley, Edward ;

Yang, Kun ;

Hong, Linda ;

Vinogradova, Ekaterina V. ;

Suciu, Radu ;

Kovalenko, Ilya ;

Karnak, David ;

Morgan, Cynthia A. ;

Chtcherbinine, Mikhail ;

Buchman, Cameron ;

Huddle, Brandt ;

Barraza, Scott ;

Morgan, Meredith ;

Bernstein, Kara A. ;

Yoon, Euisik ;

Lombard, David B. ;

Bild, Andrea ;

Mehta, Geeta ;

Romero, Iris ;

Chiang, Chun-Yi ;

Landen, Charles ;

Cravatt, Benjamin ;

Hurley, Thomas D. ;

Larsen, Scott D. ;

Buckanovich, Ronald J. .

CELL REPORTS, 2019, 26 (11) :3061-+

[8] A novel role for ketoconazole in hepatocellular carcinoma treatment: linking PTGS2 to mitophagy machinery [J].

Chen, Hai-Ning ;

Chen, Yan ;

Zhou, Zong-Guang ;

Wei, Yuquan ;

Huang, Canhua .

AUTOPHAGY, 2019, 15 (04) :733-734

[9] Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma [J].

Chen, Yan ;

Chen, Hai-Ning ;

Wang, Kui ;

Zhang, Lu ;

Huang, Zhao ;

Liu, Jiayang ;

Zhang, Zhe ;

Luo, Maochao ;

Lei, Yunlong ;

Peng, Yong ;

Zhou, Zong-Guang ;

Wei, Yuquan ;

Huang, Canhua .

JOURNAL OF HEPATOLOGY, 2019, 70 (01) :66-77

[10] Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis [J].

Cheng, Gang ;

Zhang, Qi ;

Pan, Jing ;

Lee, Yongik ;

Ouari, Olivier ;

Hardy, Micael ;

Zielonka, Monika ;

Myers, Charles R. ;

Zielonka, Jacek ;

Weh, Katherine ;

Chang, Andrew C. ;

Chen, Guoan ;

Kresty, Laura ;

Kalyanaraman, Balaraman ;

You, Ming .

NATURE COMMUNICATIONS, 2019, 10 (1)

← 1 2 3 4 5 6 7 →