Immunocytochemical detection of superoxide dismutases (SODs) in the periodontal Ruffini endings of the rat incisor

被引：3
作者：
Yamamoto, H
Hayashi, S
Nakakura-Ohshima, K
Kawano, Y
Nozawa-Inoue, K
Ohshima, H
Maeda, T
机构：
[1] Niigata Univ, Grad Sch Med & Dent Sci, Dept Oral Biol Sci, Div Oral & Maxillofacial Anat, Niigata 9518514, Japan
[2] Niigata Univ, Grad Sch Med & Dent Sci, Dept Oral Hlth Sci, Div Pediat Dent, Niigata 9518514, Japan
[3] Niigata Univ, Dent Hosp, Polyclin Intens Oral Care Unit, Niigata 9518514, Japan
来源：
BRAIN RESEARCH | 2001年 / 905卷 / 1-2期
关键词：
superoxide dismutases (SODs); mechanoreceptor; Ruffini ending; periodontal ligament;
D O I：
10.1016/S0006-8993(01)02458-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The expression of immunoreactivities for superoxide dismutases (SODs), Mn-SOD and Cu/Zn-SOD. was immunohistochemically investigated in the lingual periodontal ligament and toe pads of adult rats. Immunocytochemistry for SODs revealed that the axon terminals of both the periodontal Ruffini endings and cutaneous Meissner's corpuscles showed mitochondrial Mn-SOD immunoreactivity, but not cytosolic Cu/Zn-SOD immunoreactivity, indicating Mn-SOD is a useful marker for identifying the mechanoreceptors. It is likely that Mn-SOD in the axon terminals of mechanoreceptors exerts protective action against nerve injury and neuronal death under severe conditions, serving to scavenge free radicals from the axon terminals. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：232 / 235
页数：4
相关论文
共 23 条
[1]  
ALLEN RG, 1991, P SOC EXP BIOL MED, V196, P117
[2]  
Andres K H, 1973, HDB SENSORY PHYSIOLO, VII, P3
[3]   PILO-RUFFINI COMPLEX - NON-SINUS HAIR AND ASSOCIATED SLOWLY-ADAPTING MECHANORECEPTOR IN PRIMATE FACIAL SKIN [J].
BIEMESDERFER, D ;
MUNGER, BL ;
BINCK, J ;
DUBNER, R .
BRAIN RESEARCH, 1978, 142 (02) :197-222
[4]  
Byers MR., 1997, ACTA MED DENT HELV, V2, P116
[5]   STRUCTURE AND FUNCTION OF SLOWLY ADAPTING TYPE II MECHANORECEPTOR IN HAIRY SKIN [J].
CHAMBERS, MR ;
ANDRES, KH ;
IGGO, A ;
DUERING, MV .
QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 1972, 57 (04) :417-+
[6]   COPPER, ZINC SUPEROXIDE-DISMUTASE IS PRIMARILY A CYTOSOLIC PROTEIN IN HUMAN-CELLS [J].
CRAPO, JD ;
OURY, T ;
RABOUILLE, C ;
SLOT, JW ;
CHANG, LY .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10405-10409
[7]  
Dubovy P, 1996, MICROSC RES TECHNIQ, V34, P362
[8]   BIOLOGY OF OXYGEN RADICALS [J].
FRIDOVICH, I .
SCIENCE, 1978, 201 (4359) :875-880
[9]   THE VISUALIZATION OF CARDIOVASCULAR INNERVATION IN THE GUINEA-PIG USING AN ANTISERUM TO PROTEIN GENE-PRODUCT 9.5 (PGP 9.5) [J].
GULBENKIAN, S ;
WHARTON, J ;
POLAK, JM .
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1987, 18 (03) :235-247
[10]   OXYGEN RADICALS AND THE NERVOUS-SYSTEM [J].
HALLIWELL, B ;
GUTTERIDGE, JMC .
TRENDS IN NEUROSCIENCES, 1985, 8 (01) :22-26
123