State of art and advances on the treatment of bone metastases from breast cancer: a concise review

被引：16

作者：

Rossi, Lorenzo ^{[1
,2
]}

Longhitano, Claudio ^{[1
,2
]}

Kola, Florenc ^{[3
]}

Del Grande, Maria ^{[1
]}

机构：

[1] Inst Oncol Southern Switzerland IOSI, Bellinzona, Switzerland

[2] Breast Unit Southern Switzerland CSSI, Lugano, Switzerland

[3] Ente Osped Cantonale, Dept Internal Med, Bellinzona, Switzerland

来源：

CHINESE CLINICAL ONCOLOGY | 2020年 / 9卷 / 02期

关键词：

Breast cancer (BC); bone metastases; bisphosphonates; denosumab; biomarkers; SKELETAL-RELATED EVENTS; ZOLEDRONIC ACID; ANTITUMOR-ACTIVITY; PAIN PALLIATION; POSTMENOPAUSAL WOMEN; ADJUVANT TREATMENT; IMPROVED SURVIVAL; ORAL CLODRONATE; SOLID TUMORS; DOUBLE-BLIND;

D O I：

10.21037/cco.2020.01.07

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bone is one of the most common metastatic sites in metastatic breast cancer (mBC). The presence of bone metastases can lead to various complications including pain, spinal cord compression, hypercalcaemia, pathological fractures. The treatment of bone metastases of breast cancer (BC) is mainly based on the biological characteristics of the primary tumour, but there are also specific treatments for bone lesions including bone modifiers, radionuclides, or localized treatments such as radiotherapy, surgery or vertebroplasty. In this review, we analyse the state of art of the common treatments and the advances of bone metastases of BC. Finally, we summarize the state of art of biomarkers in diagnosis, prognosis and prediction to therapy.

引用

页数：11

共 86 条

[61] Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases [J].

Ross, Michael H. ;

Esser, Alison K. ;

Fox, Gregory C. ;

Schmieder, Anne H. ;

Yang, Xiaoxia ;

Hu, Grace ;

Pan, Dipanjan ;

Su, Xinming ;

Xu, Yalin ;

Novack, Deborah V. ;

Walsh, Thomas ;

Colditz, Graham A. ;

Lukaszewicz, Gabriel H. ;

Cordell, Elizabeth ;

Novack, Joshua ;

Fitzpatrick, James A. J. ;

Waning, David L. ;

Mohammad, Khalid S. ;

Guise, Theresa A. ;

Lanza, Gregory M. ;

Weilbaecher, Katherine N. .

CANCER RESEARCH, 2017, 77 (22) :6299-6312

[62] Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases [J].

Saad, F. ;

Brown, J. E. ;

Van Poznak, C. ;

Ibrahim, T. ;

Stemmer, S. M. ;

Stopeck, A. T. ;

Diel, I. J. ;

Takahashi, S. ;

Shore, N. ;

Henry, D. H. ;

Barrios, C. H. ;

Facon, T. ;

Senecal, F. ;

Fizazi, K. ;

Zhou, L. ;

Daniels, A. ;

Carriere, P. ;

Dansey, R. .

ANNALS OF ONCOLOGY, 2012, 23 (05) :1341-1347

[63] Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in node-positive breast cancer patients [J].

Saarto, T ;

Vehmanen, L ;

Virkkunen, P ;

Blomqvist, C .

ACTA ONCOLOGICA, 2004, 43 (07) :650-656

[64] A novel gene expression signature for bone metastasis in breast carcinomas [J].

Savci-Heijink, C. Dilara ;

Halfwerk, Hans ;

Koster, Jan ;

van de Vijver, Marc J. .

BREAST CANCER RESEARCH AND TREATMENT, 2016, 156 (02) :249-259

[65] Phase II studies of two different schedules of dasatinib in bone metastasis predominant metastatic breast cancer: SWOG S0622 [J].

Schott, Anne F. ;

Barlow, William E. ;

Van Poznak, Catherine H. ;

Hayes, Daniel F. ;

Moinpour, Carol M. ;

Lew, Danika L. ;

Dy, Philip A. ;

Keller, Evan T. ;

Keller, Jill M. ;

Hortobagyi, Gabriel N. .

BREAST CANCER RESEARCH AND TREATMENT, 2016, 159 (01) :87-95

[66]

Serafini AN, 2001, J NUCL MED, V42, P895

[67] Cost-Effectiveness Analysis of Monthly Zoledronic Acid, Zoledronic Acid Every 3 Months, and Monthly Denosumab in Women With Breast Cancer and Skeletal Metastases: CALGB 70604 (Alliance) [J].

Shapiro, Charles L. ;

Moriarty, James P. ;

Dusetzina, Stacie ;

Himelstein, Andrew L. ;

Foster, Jared C. ;

Grubbs, Stephen S. ;

Novotny, Paul J. ;

Borah, Bijan J. .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (35) :3949-+

[68] Role of rebiopsy in metastatic breast cancer at progression [J].

Sharma, Manish ;

Gogia, Ajay ;

Deo, Suryanarayana S. V. ;

Mathur, Sandeep .

CURRENT PROBLEMS IN CANCER, 2019, 43 (05) :438-442

[69]

Siemionow Krzysztof, 2007, Curr Opin Support Palliat Care, V1, P323, DOI 10.1097/SPC.0b013e3282f33714

[70] Influence of zoledronic acid on disseminated tumor cells in primary breast cancer patients [J].

Solomayer, E. -F. ;

Gebauer, G. ;

Hirnle, P. ;

Janni, W. ;

Lueck, H. -J. ;

Becker, S. ;

Huober, J. ;

Kraemer, B. ;

Wackwitz, B. ;

Wallwiener, D. ;

Fehm, T. .

ANNALS OF ONCOLOGY, 2012, 23 (09) :2271-2277

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