Alterations in brain white matter contributing to age-related slowing of task switching performance: The role of radial diffusivity and magnetization transfer ratio

被引:12
作者
Serbruyns, Leen [1 ]
Leunissen, Inge [1 ]
van Ruitenbeek, Peter [1 ]
Pauwels, Lisa [1 ]
Caeyenberghs, Karen [1 ,2 ]
Solesio-Jofre, Elena [1 ]
Geurts, Monique [1 ]
Cuypers, Koen [1 ,3 ]
Meesen, Raf L. [1 ,3 ]
Sunaert, Stefan [4 ]
Leemans, Alexander [5 ]
Swinnen, Stephan P. [1 ,6 ]
机构
[1] Katholieke Univ Leuven, Grp Biomed Sci, Motor Control Lab, Movement Control & Neuroplast Res Grp, Leuven, Belgium
[2] Australian Catholic Univ, Fac Hlth Sci, Sch Psychol, Sydney, NSW 2059, Australia
[3] Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium
[4] Katholieke Univ Leuven, Med Imaging Res Ctr, Grp Biomed Sci, Leuven, Belgium
[5] Univ Med Ctr Utrecht, Image Sci Inst, Utrecht, Netherlands
[6] Katholieke Univ Leuven, Leuven Res Inst Neurosci & Dis LIND, Leuven, Belgium
关键词
aging; mixing cost; switch cost; diffusion tensor imaging; magnetization transfer imaging; mediation; MULTIPLE-SCLEROSIS; BASAL GANGLIA; OLDER-ADULTS; IN-VIVO; CORPUS-CALLOSUM; BASIC PROCESS; NERVE-FIBERS; GRAY-MATTER; TENSOR; DEMYELINATION;
D O I
10.1002/hbm.23297
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Successfully switching between tasks is critical in many daily activities. Age-related slowing of this switching behavior has been documented extensively, but the underlying neural mechanisms remain unclear. Here, we investigated the contribution of brain white matter changes associated with myelin alterations to age-related slowing of switching performance. Diffusion tensor imaging derived radial diffusivity (RD) and magnetization transfer imaging derived magnetization transfer ratio (MTR) were selected as myelin sensitive measures. These metrics were studied in relation to mixing cost (i.e., the increase in reaction time during task blocks that require task switching) on a local-global switching task in young (n = 24) and older (n = 22) adults. Results showed that higher age was associated with widespread increases in RD and decreases in MTR, indicative of white matter deterioration, possibly due to demyelination. Older adults also showed a higher mixing cost, implying slowing of switching performance. Finally, mediation analyses demonstrated that decreases in MTR of the bilateral superior corona radiata contributed to the observed slowing of switching performance with increasing age. These findings provide evidence for a role of cortico-subcortical white matter changes in task switching performance deterioration with healthy aging. Hum Brain Mapp 37:4084-4098, 2016. (c) 2016 Wiley Periodicals, Inc.
引用
收藏
页码:4084 / 4098
页数:15
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