Orthoscuticellines A-E, β-Carboline Alkaloids from the Bryozoan Orthoscuticella ventricosa Collected in Australia

被引：28

作者：

Kleks, Guy ^{[1
]}

Duffy, Sandra ^{[2
]}

Lucantoni, Leonardo ^{[2
]}

Avery, Vicky M. ^{[2
]}

Carroll, Anthony R. ^{[1
]}

机构：

[1] Griffith Univ, Gold Coast, Qld, Australia

[2] Griffith Univ, Brisbane, Qld, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2020年 / 83卷 / 02期

关键词：

MARINE BRYOZOAN;

D O I：

10.1021/acs.jnatprod.9b00933

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Antiplasmodial high-throughput screening of extracts derived from marine invertebrates collected from northern NSW, Australia, resulted in the methanol extract of the bryozoan Orthoscuticella ventricosa being identified as inhibitory toward the 3D7 strain of Plasmodium falciparum. Purification of this extract resulted in two new bis-beta-carbolines that possess a cyclobutane moiety, orthoscuticellines A and B (1 and 2), three new beta-carboline alkaloids, orthoscuticellines C-E (3-5), and six known compounds, 1-ethyl-4-methylsulfone-beta-carboline (6), 1-ethyl-beta-carboline (7), 1-acetyl-beta-carboline (8) 1-(1'-hydroxyethyl)-beta-carboline (9), 1-methoxycarbonyl-beta-carboline (10), and 1-vinyl-beta-carboline (11). The structures of all compounds were determined from analysis of MS and 1D and 2D NMR data. The compounds showed modest antiplasmodial activity against P. falciparum in the range of 12-21 mu M.

引用

页码：422 / 428

页数：7