Therapeutic potentials of fasudil in liver fibrosis

被引：5

作者：

Xi, Yue ^{[1
,2
]}

Xu, Peng-Fei ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Ctr Pharmacogenet, 323 Salk Pavil,335 Sutherland Dr, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Dept Pharmaceut Sci, 323 Salk Pavil,335 Sutherland Dr, Pittsburgh, PA 15261 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2021年 / 27卷 / 45期

关键词：

Fasudil; Liver fibrosis; Natural killer cell; Hepatic stellate cell; Clinical therapeutic drug; RHO-KINASE INHIBITOR; HEPATIC-FIBROSIS; HYDROCHLORIDE; INFLAMMATION; RATS;

D O I：

10.3748/wjg.v27.i45.7859

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Fasudil has the potential to prevent liver fibrosis by activating natural killer cells and inhibiting the proliferation of hepatic stellate cells. Fasudil may be a promising clinical therapeutic drug for the prevention and treatment of liver fibrosis.

引用

页码：7859 / 7861

页数：3

共 7 条

[1] Reversal of NASH fibrosis with pharmacotherapy [J].

Alukal, Joseph J. ;

Thuluvath, Paul J. .

HEPATOLOGY INTERNATIONAL, 2019, 13 (05) :534-545

[2] Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells [J].

Han, Qiu-Ju ;

Mu, Yong-Liang ;

Zhao, Hua-Jun ;

Zhao, Rong-Rong ;

Guo, Quan-Juan ;

Su, Yu-Hang ;

Zhang, Jian .

WORLD JOURNAL OF GASTROENTEROLOGY, 2021, 27 (24) :3581-3594

[3] Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats [J].

Ikeda, Hitoshi ;

Kume, Yukio ;

Tejima, Kazuaki ;

Tomiya, Tomoaki ;

Nishikawa, Takako ;

Watanabe, Naoko ;

Ohtomo, Natsuko ;

Arai, Masahiro ;

Arai, Chihiro ;

Omata, Masao ;

Fujiwara, Kenji ;

Yatomi, Yutaka .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2007, 293 (04) :G911-G917

[4] Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C [J].

Tanwar, Sudeep ;

Rhodes, Freya ;

Srivastava, Ankur ;

Trembling, Paul M. ;

Rosenberg, William M. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2020, 26 (02) :109-133

[5]

Xie Y, 2018, EUR REV MED PHARMACO, V22, P5665, DOI 10.26355/eurrev_201809_15834

[6] Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage - Results of a randomized trial of fasudil hydrochloride versus nimodipine [J].

Zhao, Jizong ;

Zhou, Dingbiao ;

Guo, Jing ;

Ren, Zyuan ;

Zhou, Liangfu ;

Wang, Shuo ;

Xu, Bainan ;

Wang, Renzhi .

NEUROLOGIA MEDICO-CHIRURGICA, 2006, 46 (09) :421-427

[7] Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes [J].

Zhou Hong ;

Fang Caixia ;

Zhang Lihui ;

Deng Yonggui ;

Wang Mian ;

Meng Fengling .

CHINESE MEDICAL JOURNAL, 2014, 127 (02) :225-231

← 1 →