Prevalence of Fatigue, Pain, and Affective Disorders in Adults With Duchenne Muscular Dystrophy and Their Associations With Quality of Life

被引:85
作者
Pangalila, Robert F. [1 ,2 ]
van den Bos, Geertrudis A. [3 ]
Bartels, Bart [1 ,2 ]
Bergen, Michael [2 ]
Stam, Henk J. [1 ]
Roebroeck, Marij E. [1 ,2 ]
机构
[1] Erasmus Univ, Med Ctr, Dept Rehabil Med & Phys Therapy, Rotterdam, Netherlands
[2] Rijndam Rehabil, Rotterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Social Med, NL-1105 AZ Amsterdam, Netherlands
来源
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION | 2015年 / 96卷 / 07期
关键词
Adult; Fatigue; Mood disorders; Muscular dystrophy; Duchenne; Pain; Quality of life; Rehabilitation; NEUROMUSCULAR DISEASE; HOSPITAL ANXIETY; DEPRESSION SCALE; MUSCLE DISEASE; DISABILITY; SCLEROSIS; SEVERITY; CHILDREN; SF-36;
D O I
10.1016/j.apmr.2015.02.012
中图分类号
R49 [康复医学];
学科分类号
100215 ;
摘要
Objectives: To assess the prevalence of fatigue, pain, anxiety, and depression in adults with Duchenne muscular dystrophy (DMD), and to analyze their relationship with health-related quality of life. Design: Cross-sectional study. Setting: Home of participants. Participants: Adults (N=80) with DMD. Interventions: Not applicable. Main Outcome Measures: Fatigue was assessed with the Fatigue Severity Scale; pain with 1 item of the Medical Outcomes Study 36-Item Short-Form Health Survey and by interview; and anxiety and depression by using the Hospital Anxiety and Depression Scale. Health-related quality of life was assessed using the World Health Organization Quality of Life Scale Brief Version. Associations between these conditions and quality of life were assessed by means of univariate and multivariate logistic regression analyses. Results: Symptoms of fatigue (40.5%), pain (73.4%), anxiety (24%), and depression (19%) were frequently found. Individuals often had multiple conditions. Fatigue was related to overall quality of life and to the quality-of-life domains of physical health and environment; anxiety was related to the psychological domain. Conclusions: Fatigue, pain, anxiety, and depression, potentially treatable symptoms, occur frequently in adults with DMD and significantly influence health-related quality of life. (C) 2015 by the American Congress of Rehabilitation Medicine
引用
收藏
页码:1242 / 1247
页数:6
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