Detection of microcystin-metal complexes by using cryospray ionization-Fourier transform ion cyclotron resonance mass spectrometry

被引：28

作者：

Saito, Kazunori ^{[1
]}

Sei, Yoshihisa ^{[2
]}

Miki, Shinichi ^{[1
]}

Yamaguchi, Kentaro ^{[2
]}

机构：

[1] Bruker Dalton KK, Kanagawa Ku, Kanagawa 2210022, Japan

[2] Tokushima Bunri Univ, Fac Pharmaceut Sci, Kagawa 7692193, Japan

来源：

TOXICON | 2008年 / 51卷 / 08期

关键词：

microcystin; microcystin-metal complex; CryoSpray; FT-ICR-MS;

D O I：

10.1016/j.toxicon.2008.03.026

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Complexes of microcystins (MCs) and metal ions were detected with mass spectrometry. To observe the MCs-metals complexes, CryoSpray ionization ion source was developed and it was equipped on a commercial Fourier transform ion resonance mass spectrometer. Mixtures of two MCs and five metals were applied to Fourier transform ion cyclotron resonance mass spectrometry coupled with CryoSpray. The analyses showed complexes of MC-LR-Fe(II), -Zn, -Cu, -Mg, MC-RR-Fe(II), -Zn, -Cu, and -Mg but MC-LR-Fe(III) and MC-RR-Fe(III) were not observed. Present study suggested that Mcs may play roles in metal ion uptake and/or accumulation in the algal cells. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1496 / 1498

页数：3

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