Retinal cell fate determination and bHLH factors

被引：203
作者：
Hatakeyama, J [1 ]
Kageyama, R [1 ]
机构：
[1] Kyoto Univ, Inst Virus Res, Sakyo Ku, Kyoto 6068507, Japan
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 01期
基金：
日本学术振兴会;
关键词：
bHLH; gliogenesis; homeodomain; neurogenesis; progenitor;
D O I：
10.1016/j.semcdb.2003.09.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Retinal development is controlled antagonistically by multiple basic helix-loop-helix (bHLH) transcriptional activators and repressors. bHLH repressors suppress bHLH activators and promote maintenance of progenitors and generation of glial cells. In contrast, bHLH activators override activities of bHLH repressors and promote neuronal differentiation. However, bHLH activators alone are not sufficient but homeodomain factors are additionally required for neuronal subtype specification. It is likely that homeodomain factors regulate the layer specificity but not the neuronal fate while bHLH activators determine the neuronal fate within the homedomain factor-specified layers. Thus, combinations of proper bHLH and homeodomain factors are required for neuronal subtype specification. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：83 / 89
页数：7
相关论文
共 46 条
  • [1] Ahmad I, 1995, Brain Res Dev Brain Res, V90, P184
  • [2] Notch signaling: Cell fate control and signal integration in development
    Artavanis-Tsakonas, S
    Rand, MD
    Lake, RJ
    [J]. SCIENCE, 1999, 284 (5415) : 770 - 776
  • [3] AUSTIN CP, 1995, DEVELOPMENT, V121, P3637
  • [4] Bae SK, 2000, DEVELOPMENT, V127, P2933
  • [5] Proneural genes and the specification of neural cell types
    Bertrand, N
    Castro, DS
    Guillemot, F
    [J]. NATURE REVIEWS NEUROSCIENCE, 2002, 3 (07) : 517 - 530
  • [6] Brown NL, 1998, DEVELOPMENT, V125, P4821
  • [7] Brown NL, 2001, DEVELOPMENT, V128, P2497
  • [8] Ocular retardation mouse caused by Chx10 homeobox null allele: Impaired retinal progenitor proliferation and bipolar cell differentiation
    Burmeister, M
    Novak, T
    Liang, MY
    Basu, S
    Ploder, L
    Hawes, NL
    Vidgen, D
    Hoover, F
    Goldman, D
    Kalnins, VI
    Roderick, TH
    Taylor, BA
    Hankin, MH
    McInnes, RR
    [J]. NATURE GENETICS, 1996, 12 (04) : 376 - 384
  • [9] The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates
    Cepko, CL
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 1999, 9 (01) : 37 - 46
  • [10] Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes
    Chen, SM
    Wang, QL
    Nie, ZQ
    Sun, H
    Lennon, G
    Copeland, NG
    Gilbert, DJ
    Jenkins, NA
    Zack, DJ
    [J]. NEURON, 1997, 19 (05) : 1017 - 1030
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