DNA Double-Strand Break Repairs and Their Application in Plant DNA Integration

被引:15
作者
Shen, Hexi [1 ,2 ]
Li, Zhao [1 ,2 ]
机构
[1] Shandong Jianzhu Univ, Sch Municipal & Environm Engn, Jinan 250101, Peoples R China
[2] Shandong Jianzhu Univ, Resources & Environm Innovat Inst, Jinan 250101, Peoples R China
关键词
DSB; DNA repair; HR; NHEJ; T-DNA integration; gene targeting; AGROBACTERIUM T-DNA; REPLICATION PROTEIN-A; HOMOLOGOUS RECOMBINATION; POLYMERASE THETA; DAMAGE RESPONSE; ILLEGITIMATE RECOMBINATION; TARGETED INTEGRATION; LIGASE-IV; GENE; ARABIDOPSIS;
D O I
10.3390/genes13020322
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Double-strand breaks (DSBs) are considered to be one of the most harmful and mutagenic forms of DNA damage. They are highly toxic if unrepaired, and can cause genome rearrangements and even cell death. Cells employ two major pathways to repair DSBs: homologous recombination (HR) and non-homologous end-joining (NHEJ). In plants, most applications of genome modification techniques depend on the development of DSB repair pathways, such as Agrobacterium-mediated transformation (AMT) and gene targeting (GT). In this paper, we review the achieved knowledge and recent advances on the DNA DSB response and its main repair pathways; discuss how these pathways affect Agrobacterium-mediated T-DNA integration and gene targeting in plants; and describe promising strategies for producing DSBs artificially, at definite sites in the genome.
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页数:16
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