Stem cells and the circadian clock

被引：75
|
作者：
Weger, Meltem [1 ,5 ]
Diotel, Nicolas [2 ]
Dorsemans, Anne-Claire [2 ]
Dickmeis, Thomas [3 ]
Weger, Benjamin D. [4 ]
机构：
[1] Univ Birmingham, Ctr Endocrinol Diabet & Metab, Birmingham, W Midlands, England
[2] Univ La Reunion, INSERM, UMR 1188, Diabet Atherothrombose Therapies Reunion Ocean In, St Denis De La Reunion, France
[3] Karlsruhe Inst Technol, Inst Toxicol & Genet, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany
[4] Nestle Inst Hlth Sci SA, EPFL Innovat Pk,Batiment H, CH-1015 Lausanne, Switzerland
[5] Ecole Polytech Fed Lausanne, Brain Mind Inst, CH-1015 Lausanne, Switzerland
来源：
DEVELOPMENTAL BIOLOGY | 2017年 / 431卷 / 02期
关键词：
Circadian clock; Stem cell; Development; Vertebrate; Adult neurogenesis; REV-ERB-ALPHA; ARNT-LIKE; RADIAL GLIAL-CELLS; HUMAN BONE-MARROW; HEMATOPOIETIC STEM; ADULT NEUROGENESIS; PROGENITOR CELLS; MOLECULAR CLOCK; LOCOMOTOR-ACTIVITY; GENE-EXPRESSION;
D O I：
10.1016/j.ydbio.2017.09.012
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The circadian timing system is a complex biological network of interacting circadian clocks that regulates 24 h rhythms of behavioral and physiological processes. One intriguing observation is that stem cell homeostasis is subject to circadian clock regulation. Rhythmic oscillations have been observed in a variety of embryonic and adult stem cell dependent processes, such as hematopoietic progenitor cell migration, the hair follicle cycle, bone remodeling, regenerative myogenesis and neurogenesis. This review aims to discuss the nature of the circadian clock in embryonic stem cells and how it changes during differentiation. Furthermore, it will examine how the circadian clock contributes to adult stem cell function in different tissues of the body with an emphasis on the brain and adult neurogenesis.
引用
收藏
页码：111 / 123
页数：13
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