Preliminary Evaluation of a Water Soluble Chlorin Photosensitizer

被引：2

作者：

Zou, Jian ^{[1
]}

Huang, Qiuyan ^{[1
]}

Li, Weijun ^{[1
]}

Zou, Shulin ^{[1
]}

Han, Zhen ^{[2
]}

Huang, Zheng ^{[1
]}

机构：

[1] Fujian Normal Univ, MOE Key Lab OptoElect Sci & Technol Med, Fuzhou 350007, Fujian, Peoples R China

[2] Guilin Huiang Biopharmoceut Co Ltd, Guilin 541004, Peoples R China

来源：

MEDICAL LASER APPLICATIONS AND LASER-TISSUE INTERACTIONS VIII | 2017年 / 10417卷

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1117/12.2291936

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Some of the key optical properties of a new water soluble chlorine (YLG-1) were evaluated. The sensitizer has a strong absorption at 398 nm and 655 nm in DMSO. A strong red fluorescence is detected under the excitation of 398 nm. The fluorescence life time is approximately 5 ns and fluorescence quantum yield 20%. The sensitizer does not accumulate in normal skin after topical use or IV injection. Preliminary in vivo results suggest that this novel chlorine causes little cutaneous phototoxicity. Its potentials in photodynamic therapy (PDT) deserve further study.

引用

页数：3