Indirect androgen doping by oestrogen blockade in sports

被引:57
作者
Handelsman, D. J. [1 ]
机构
[1] Univ Sydney, Dept Androl, ANZAC Res Inst, Concord Hosp, Sydney, NSW 2139, Australia
关键词
oestrogen; androgen; sports doping; antioestrogen; aromatase inhibitor; performance enhancement; elite sport; power sport;
D O I
10.1038/bjp.2008.150
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Androgens can increase muscular mass and strength and remain the most frequently abused and widely available drugs used in sports doping. Banning the administration of natural or synthetic androgens has led to a variety of strategies to circumvent the ban of the most effective ergogenic agents for power sports. Among these, a variety of indirect androgen doping strategies aiming to produce a sustained rise in endogenous testosterone have been utilized. These include oestrogen blockade by drugs that act as oestrogen receptor antagonists (antioestrogen) or aromatase inhibitors. The physiological and pharmacological basis for the effects of oestrogen blockade in men, but not women, are reviewed.
引用
收藏
页码:598 / 605
页数:8
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