Autologous lipoaspirate as a new treatment of vulvar lichen sclerosus: A review on literature

被引：5

作者：

van der Sluis, Nanouk ^{[1
,2
]}

Scheers, Esther C. A. H. ^{[3
]}

Krenning, Guido ^{[4
,5
]}

van der Lei, Berend ^{[1
]}

Oonk, Maaike H. M. ^{[3
]}

van Dongen, Joris A. ^{[6
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Plast Surg, Groningen, Netherlands

[2] Med Spectrum Twente, Dept Plast Reconstruct & Hand Surg, Enschede, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynecol, Groningen, Netherlands

[4] Univ Groningen, Dept Pathol & Med Biol, Groningen, Netherlands

[5] Univ Med Ctr Groningen, Groningen, Netherlands

[6] Univ Utrecht, Utrecht Univ Med Ctr, Dept Plast Reconstruct & Hand Surg, Utrecht, Netherlands

来源：

EXPERIMENTAL DERMATOLOGY | 2022年 / 31卷 / 05期

关键词：

ageing; dermal; fibrosis; lichen sclerosus; lipoaspirate; regeneration; stem cells; stromal vascular fraction; vulvar; STROMAL-VASCULAR FRACTION; PLATELET-RICH PLASMA; EXTRACELLULAR-MATRIX PROTEINS; STEM-CELLS; ADIPOSE-TISSUE; GROWTH-FACTOR; REGENERATIVE APPROACH; SYSTEMIC-SCLEROSIS; FAT GRAFT; SCLERODERMA;

D O I：

10.1111/exd.14561

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Lichen sclerosus (LS) is a chronic inflammatory dermatosis that mostly affects the genital and anal skin areas. Symptoms may vary from pruritis and pain to sexual dysfunction; however, LS can also be asymptomatic. LS occurs at all ages and in both sexes. Approximately 5% of all women affected by vulvar LS will develop vulvar squamous cell carcinoma. Topical treatment is safe but less effective resulting in chronic course in most patients, who suffer from persistent itching and pain. In severe cases of therapy-resistant LS, there is no adequate treatment. Fat grafting is a novel regenerative therapy to reduce dermal fibrosis. The therapeutic effect of adipose tissue grafts for LS is already investigated in various pioneering studies. This review provides an overview of these studies and the putative mechanisms-of-action of fat grafting to treat LS.

引用

页码：689 / 699

页数：11

共 114 条

[1]

Abramov Y, 1996, Obstet Gynecol Surv, V51, P193, DOI 10.1097/00006254-199603000-00023

[2] Fat Grafting Improves Fibrosis and Scarring in Vulvar Lichen Sclerosus: Results From a Prospective Cohort Study [J].