Emerging biomarkers and screening for cognitive frailty

被引：45
作者：
Ruan, Qingwei [1 ,2 ]
D'Onofrio, Grazia [3 ,4 ]
Sancarlo, Daniele [3 ,4 ]
Greco, Antonio [3 ,4 ]
Lozupone, Madia [5 ]
Seripa, Davide [3 ,4 ]
Panza, Francesco [3 ,4 ,5 ,6 ]
Yu, Zhuowei [1 ,2 ]
机构：
[1] Fudan Univ, Huadong Hosp, Shanghai Key Lab Clin Geriatr, Dept Geriatr, Shanghai 200040, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Shanghai Inst Geriatr & Gerontol, Res Ctr Aging & Med, Shanghai 200040, Peoples R China
[3] IRCCS Casa Sollievo Sofferenza, Geriatr Unit, Foggia, Italy
[4] IRCCS Casa Sollievo Sofferenza, Lab Gerontol & Geriatr, Dept Med Sci, Foggia, Italy
[5] Univ Bari Aldo Moro, Dept Basic Med Neurosci & Sense Organs, Neurodegenerat Dis Unit, Bari, Italy
[6] Univ Bari Aldo Moro, Dept Clin Res Neurol, Pia Fdn Cardinale G Panico, Lecce, Italy
来源：
AGING CLINICAL AND EXPERIMENTAL RESEARCH | 2017年 / 29卷 / 06期
关键词：
Alzheimer's disease; Biomarkers; Cognitive screening; Dementia; Frailty; Mild cognitive impairment; ALZHEIMERS ASSOCIATION WORKGROUPS; AMYLOID-BETA OLIGOMERS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; VASCULAR DEMENTIA; CEREBROSPINAL-FLUID; RISK SYNDROME; OLDER-ADULTS; DISEASE; IMPAIRMENT;
D O I：
10.1007/s40520-017-0741-8
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Physical frailty and cognitive frailty are two important targets of secondary intervention in aging research to narrow the gap between life and health span. The objective of the present narrative review was to examine clinical and epidemiological studies investigating the recently proposed construct of cognitive frailty and its subtypes, with a focus on operational definitions, clinical criteria, and emerging biomarkers potentially useful for the screening of this novel entity. Both physical frailty and frailty indexes with a multidimensional nature were associated with late-life cognitive impairment/decline, incident dementia, Alzheimer's disease (AD), mild cognitive impairment, vascular dementia, non-AD dementias, and AD pathology proposing cognitive frailty as a clinical entity with cognitive impairment related to physical causes with a potential reversibility. The new clinical and research AD criteria established by the National Institute on Aging-Alzheimer's Association and the American Psychiatric Association could improve the differential diagnosis of cognitive impairment within the cognitive frailty construct. The emerging biomarkers of sarcopenia, physical frailty, and cognitive impairment will provide the basis to establish more reliable clinical and research criteria for cognitive frailty, using different operational definitions for frailty and cognitive impairment and useful clinical, biological, and imaging markers for this novel clinical construct.
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收藏
页码：1075 / 1086
页数：12
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