Ribo-gnome: The big world of small RNAs

被引：1065
作者：
Zamore, PD [1 ]
Haley, B [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA
来源：
SCIENCE | 2005年 / 309卷 / 5740期
关键词：
D O I：
10.1126/science.1111444
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Small RNA guides-microRNAs, small interfering RNAs, and repeat-associated small interfering RNAs, 21 to 30 nucleotides in length-shape diverse cellular pathways, from chromosome architecture to stem cell maintenance. Fifteen years after the discovery of RNA silencing, we are only just beginning to understand the depth and complexity of how these RNAs regulate gene expression and to consider their role in shaping the evolutionary history of higher eukaryotes.
引用
收藏
页码：1519 / 1524
页数：6
相关论文
共 95 条
[1]   Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation [J].
Bagga, S ;
Bracht, J ;
Hunter, S ;
Massirer, K ;
Holtz, J ;
Eachus, R ;
Pasquinelli, AE .
CELL, 2005, 122 (04) :553-563
[2]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[3]   Identification of hundreds of conserved and nonconserved human microRNAs [J].
Bentwich, I ;
Avniel, A ;
Karov, Y ;
Aharonov, R ;
Gilad, S ;
Barad, O ;
Barzilai, A ;
Einat, P ;
Einav, U ;
Meiri, E ;
Sharon, E ;
Spector, Y ;
Bentwich, Z .
NATURE GENETICS, 2005, 37 (07) :766-770
[4]   Dicer is essential for mouse development [J].
Bernstein, E ;
Kim, SY ;
Carmell, MA ;
Murchison, EP ;
Alcorn, H ;
Li, MZ ;
Mills, AA ;
Elledge, SJ ;
Anderson, KV ;
Hannon, GJ .
NATURE GENETICS, 2003, 35 (03) :215-217
[5]   Role for a bidentate ribonuclease in the initiation step of RNA interference [J].
Bernstein, E ;
Caudy, AA ;
Hammond, SM ;
Hannon, GJ .
NATURE, 2001, 409 (6818) :363-366
[6]   Principles of MicroRNA-target recognition [J].
Brennecke, J ;
Stark, A ;
Russell, RB ;
Cohen, SM .
PLOS BIOLOGY, 2005, 3 (03) :404-418
[7]   GENE REGULATION FOR HIGHER CELLS - A THEORY [J].
BRITTEN, RJ ;
DAVIDSON, EH .
SCIENCE, 1969, 165 (3891) :349-+
[8]   Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome [J].
Cam, HP ;
Sugiyama, T ;
Chen, ES ;
Chen, X ;
FitzGerald, PC ;
Grewal, SIS .
NATURE GENETICS, 2005, 37 (08) :809-819
[9]   RNA silencing genes control de novo DNA methylation [J].
Chan, SWL ;
Zilberman, D ;
Xie, ZX ;
Johansen, LK ;
Carrington, JC ;
Jacobsen, SE .
SCIENCE, 2004, 303 (5662) :1336-1336
[10]   A member of the polymerase β nucleotidyltransferase superfamily is required for RNA interference in C-elegans [J].
Chen, CCG ;
Simard, MJ ;
Tabara, H ;
Brownell, DR ;
McCollough, JA ;
Mello, CC .
CURRENT BIOLOGY, 2005, 15 (04) :378-383
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