Obesity-induced inflammatory changes in adipose tissue

被引：1348

作者：

Wellen, KE ^{[1
]}

Hotamisligil, GS ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 12期

关键词：

INDUCED INSULIN-RESISTANCE; TARGETED DISRUPTION; GENE-EXPRESSION; MACROPHAGE; PROTECTS; LEPTIN; ALPHA;

D O I：

10.1172/JCI20514

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.

引用

页码：1785 / 1788

页数：4

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