The Future of Radiation Oncology in Soft Tissue Sarcoma

被引：10
|
作者：
Naghavi, Arash O. [1 ]
Yang, George Q. [1 ]
Latifi, Kujtim [1 ]
Gillies, Robert [2 ]
McLeod, Howard [3 ]
Harrison, Louis B. [1 ]
机构：
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Radiat Oncol, Tampa, FL USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Physiol, Tampa, FL USA
[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA
来源：
CANCER CONTROL | 2018年 / 25卷 / 01期
关键词：
radiation oncology; soft tissue sarcoma; radiation; radiotherapy; POSITRON-EMISSION-TOMOGRAPHY; GENE-EXPRESSION PROFILES; CT TEXTURE ANALYSIS; LOCAL RECURRENCE; ADJUVANT CHEMOTHERAPY; NEOADJUVANT THERAPY; TUMOR RADIOSENSITIVITY; RETROSPECTIVE ANALYSIS; PATHOLOGICAL RESPONSE; CLINICAL-OUTCOMES;
D O I：
10.1177/1073274818815504
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Radiotherapy (RT) is an important component of the treatment of soft tissue sarcomas (STS) and has been traditionally incorporated with a homogenous approach despite the reality that STS displays a known heterogeneity in clinicopathologic features and treatment outcomes. In this article, we explore the principle components of personalized medicine, including genomics, radiomics, and treatment response, along with their impact on the future of radiation therapy for STS. We propose a shift in the treatment paradigm for STS from a one-size-fits-all technique to one that implements the tenets of personalized medicine and includes the framework for a potential clinical trial technique in this heterogeneous disease.
引用
收藏
页数：12
相关论文
共 50 条
  • [31] Trabectedin for Soft Tissue Sarcoma: Current Status and Future Perspectives
    Erlinda M. Gordon
    K. Kumar Sankhala
    Neal Chawla
    Sant P. Chawla
    Advances in Therapy, 2016, 33 : 1055 - 1071
  • [32] Retroperitoneal soft tissue sarcoma: An analysis of radiation and surgical treatment
    Ballo, Matthew T.
    Zagars, Gunar K.
    Pollock, Raphael E.
    Benjamin, Robert S.
    Feig, Barry W.
    Cormier, Janice N.
    Hunt, Kelly K.
    Patel, Shreyaskumar R.
    Trent, Jonathan C.
    Beddar, Sam
    Pisters, Peter W. T.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 67 (01): : 158 - 163
  • [33] Trimodality Treatment of Extremity Soft Tissue Sarcoma: Where Do We Go Now?
    Oberoi, Sapna
    Choy, Edwin
    Chen, Yen-Lin
    Scharschmidt, Thomas
    Weiss, Aaron R. R.
    CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2023, 24 (04) : 300 - 326
  • [34] LOW-DOSE NEOADJUVANT EXTERNAL BEAM RADIATION THERAPY FOR SOFT TISSUE SARCOMA
    Devisetty, Kiran
    Kobayashi, Wendy
    Suit, Herman D.
    Goldberg, Saveli I.
    Niemierko, Andrzej
    Chen, Yen-Lin E.
    Raskin, Kevin A.
    Schwab, Joseph H.
    Springfield, Dempsey S.
    Yoon, Sam S.
    Hornicek, Francis J.
    DeLaney, Thomas F.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2011, 80 (03): : 779 - 786
  • [35] The significance of a marginal excision after preoperative radiation therapy for soft tissue sarcoma of the extremity
    Dagan, Roi
    Indelicato, Daniel J.
    McGee, Lisa
    Morris, Christopher G.
    Kirwan, Jessica M.
    Knapik, Jacquelyn
    Reith, John
    Scarborough, Mark T.
    Gibbs, C. Parker
    Marcus, Robert B., Jr.
    Zlotecki, Robert A.
    CANCER, 2012, 118 (12) : 3199 - 3207
  • [36] Robust mixed electron-photon radiation therapy planning for soft tissue sarcoma
    Heng, Veng Jean
    Serban, Monica
    Renaud, Marc-Andre
    Freeman, Carolyn
    Seuntjens, Jan
    MEDICAL PHYSICS, 2023, 50 (10) : 6502 - 6513
  • [37] Soft Tissue Sarcoma, Version 2.2018
    von Mehren, Margaret
    Randall, R. Lor
    Benjamin, Robert S.
    Boles, Sarah
    Bui, Marilyn M.
    Ganjoo, Kristen N.
    George, Suzanne
    Gonzalez, Ricardo J.
    Heslin, Martin J.
    Kane, John M., III
    Keedy, Vicki
    Kim, Edward
    Koon, Henry
    Mayerson, Joel
    McCarter, Martin
    McGarry, Sean V.
    Meyer, Christian
    Morris, Zachary S.
    O'Donnell, Richard J.
    Pappo, Alberto S.
    Paz, I. Benjamin
    Petersen, Ivy A.
    Pfeifer, John D.
    Riedel, Richard F.
    Ruo, Bernice
    Schuetze, Scott
    Tap, William D.
    Wayne, Jeffrey D.
    Bergman, Mary Anne
    Scavone, Jillian L.
    JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2018, 16 (05): : 536 - 563
  • [38] Surgical margins in soft tissue sarcoma
    Stoeckle, E.
    Italiano, A.
    Stock, N.
    Kind, M.
    Kantor, G.
    Coindre, J. -M.
    Bui, B. N.
    BULLETIN DU CANCER, 2008, 95 (12) : 1199 - 1204
  • [39] Palliative Radiation Therapy for Spinal Cord Compression from Metastatic Soft Tissue Sarcoma
    Janssen, Stefan
    Bolm, Louisa
    Kaesmann, Lukas
    Bartscht, Tobias
    Rades, Dirk
    IN VIVO, 2016, 30 (04): : 529 - 531
  • [40] Unplanned resection of soft tissue sarcoma
    Chen, Cheng-Fong
    Wu, Po-Kuei
    Chen, Wei-Ming
    FORMOSAN JOURNAL OF SURGERY, 2015, 48 (04) : 117 - 120
12345