The Future of Radiation Oncology in Soft Tissue Sarcoma

被引：10
|
作者：
Naghavi, Arash O. [1 ]
Yang, George Q. [1 ]
Latifi, Kujtim [1 ]
Gillies, Robert [2 ]
McLeod, Howard [3 ]
Harrison, Louis B. [1 ]
机构：
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Radiat Oncol, Tampa, FL USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Physiol, Tampa, FL USA
[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA
来源：
CANCER CONTROL | 2018年 / 25卷 / 01期
关键词：
radiation oncology; soft tissue sarcoma; radiation; radiotherapy; POSITRON-EMISSION-TOMOGRAPHY; GENE-EXPRESSION PROFILES; CT TEXTURE ANALYSIS; LOCAL RECURRENCE; ADJUVANT CHEMOTHERAPY; NEOADJUVANT THERAPY; TUMOR RADIOSENSITIVITY; RETROSPECTIVE ANALYSIS; PATHOLOGICAL RESPONSE; CLINICAL-OUTCOMES;
D O I：
10.1177/1073274818815504
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Radiotherapy (RT) is an important component of the treatment of soft tissue sarcomas (STS) and has been traditionally incorporated with a homogenous approach despite the reality that STS displays a known heterogeneity in clinicopathologic features and treatment outcomes. In this article, we explore the principle components of personalized medicine, including genomics, radiomics, and treatment response, along with their impact on the future of radiation therapy for STS. We propose a shift in the treatment paradigm for STS from a one-size-fits-all technique to one that implements the tenets of personalized medicine and includes the framework for a potential clinical trial technique in this heterogeneous disease.
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收藏
页数：12
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