The Future of Radiation Oncology in Soft Tissue Sarcoma

被引：10

作者：

Naghavi, Arash O. ^{[1
]}

Yang, George Q. ^{[1
]}

Latifi, Kujtim ^{[1
]}

Gillies, Robert ^{[2
]}

McLeod, Howard ^{[3
]}

Harrison, Louis B. ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Radiat Oncol, Tampa, FL USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Physiol, Tampa, FL USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA

来源：

CANCER CONTROL | 2018年 / 25卷 / 01期

关键词：

radiation oncology; soft tissue sarcoma; radiation; radiotherapy; POSITRON-EMISSION-TOMOGRAPHY; GENE-EXPRESSION PROFILES; CT TEXTURE ANALYSIS; LOCAL RECURRENCE; ADJUVANT CHEMOTHERAPY; NEOADJUVANT THERAPY; TUMOR RADIOSENSITIVITY; RETROSPECTIVE ANALYSIS; PATHOLOGICAL RESPONSE; CLINICAL-OUTCOMES;

D O I：

10.1177/1073274818815504

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiotherapy (RT) is an important component of the treatment of soft tissue sarcomas (STS) and has been traditionally incorporated with a homogenous approach despite the reality that STS displays a known heterogeneity in clinicopathologic features and treatment outcomes. In this article, we explore the principle components of personalized medicine, including genomics, radiomics, and treatment response, along with their impact on the future of radiation therapy for STS. We propose a shift in the treatment paradigm for STS from a one-size-fits-all technique to one that implements the tenets of personalized medicine and includes the framework for a potential clinical trial technique in this heterogeneous disease.

引用

页数：12

共 50 条

[1] Advances in Radiation Oncology in Soft Tissue Sarcoma
Leier, Sara B.
Ahmed, Safia K.
CURRENT ONCOLOGY REPORTS, 2025, 27 (02) : 148 - 156
[2] Radiation Therapy in Metastatic Soft Tissue Sarcoma: From Palliation to Ablation
Shah, Nishant K.
Yegya-Raman, Nikhil
Jones, Joshua A.
Shabason, Jacob E.
CANCERS, 2021, 13 (19)
[3] Radiotherapy of soft tissue sarcoma
Boelke, E.
Orth, K.
Peiper, M.
Eisenberger, C. F.
Matuschek, C.
Gerber, P. A.
Fenk, R.
Engers, R.
Gripp, S.
Budach, W.
ONKOLOGE, 2009, 15 (04): : 398 - 403
[4] A multidisciplinary approach to soft-tissue sarcoma of the extremities
Nakayama, Robert
Mori, Tomoaki
Okita, Yusuke
Shiraishi, Yutaka
Endo, Makoto
EXPERT REVIEW OF ANTICANCER THERAPY, 2020, 20 (10) : 893 - 900
[5] Current state of neoadjuvant therapy of soft tissue sarcoma
Lehnhardt, M.
Schmitt, T.
Bischof, M.
Daigeler, A.
Egerer, G.
CHIRURG, 2011, 82 (11): : 995 - 1000
[6] Future directions in soft tissue sarcoma treatment
Hall, Francis
Villalobos, Victor
Wilky, Breelyn
CURRENT PROBLEMS IN CANCER, 2019, 43 (04) : 300 - 307
[7] Multidisciplinary Management of Soft Tissue Sarcoma
Nystrom, Lukas M.
Reimer, Nickolas B.
Reith, John D.
Dang, Long
Zlotecki, Robert A.
Scarborough, Mark T.
Gibbs, C. Parker, Jr.
SCIENTIFIC WORLD JOURNAL, 2013,
[8] Neoadjuvant chemotherapy in patients undergoing neoadjuvant radiation for trunk and extremity soft tissue sarcoma
Tortorello, Gabriella N.
Sharon, Cimarron E.
Ma, Kevin L. L.
Perry, Nikhita
Shabason, Jacob E.
Maki, Robert G.
Miura, John T.
Karakousis, Giorgos C.
JOURNAL OF SURGICAL ONCOLOGY, 2023, 128 (04) : 628 - 634
[9] Soft Tissue Sarcoma
Demetri, George D.
Antonia, Scott
Benjamin, Robert S.
Bui, Marilyn M.
Casper, Ephraim S.
Conrad, Ernest U., III
DeLaney, Thomas F.
Ganjoo, Kristen N.
Heslin, Martin J.
Hutchinson, Raymond J.
Kane, John M., III
Letson, G. Douglas
McGarry, Sean V.
O'Donnell, Richard J.
Paz, I. Benjamin
Pfeifer, John D.
Pollock, Raphael E.
Randall, R. Lor
Riedel, Richard F.
Schupak, Karen D.
Schwartz, Herbert S.
Thornton, Katherine
von Mehren, Margaret
Wayne, Jeffrey
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2010, 8 (06): : 630 - 674
[10] Radiation Therapy for Soft Tissue Sarcoma Indications, Timing, Benefits, and Consequences
Salerno, Kilian E.
SURGICAL CLINICS OF NORTH AMERICA, 2022, 102 (04) : 567 - 582

← 1 2 3 4 5 →